==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=22-MAR-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 15-MAY-12 4F6Z . COMPND 2 MOLECULE: BETA-LACTAMASE; . SOURCE 2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA; . AUTHOR L.B.HORTON,S.SHANKER,R.MIKULSKI,N.G.BROWN,K.PHILLIPS,E.LYKIS . 221 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 11063.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 152 68.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 22 10.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 40 18.1 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 2 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 3 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 2 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 15 6.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 19 8.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 50 22.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 4 1.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 1 0 1 0 0 1 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 0 2 1 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 5 A P 0 0 114 0, 0.0 17,-0.3 0, 0.0 3,-0.1 0.000 360.0 360.0 360.0 130.0 34.7 26.4 15.9 2 6 A D - 0 0 130 1,-0.1 14,-0.0 15,-0.1 49,-0.0 -0.144 360.0 -96.3 -62.6 149.6 34.5 22.8 17.0 3 7 A L - 0 0 20 14,-0.1 2,-0.4 12,-0.0 14,-0.2 -0.349 43.9-149.9 -55.1 139.3 31.3 20.6 16.9 4 8 A K E -A 16 0A 102 12,-2.2 12,-2.3 -3,-0.1 2,-0.4 -0.911 13.0-165.1-118.3 147.3 29.6 20.6 20.3 5 9 A I E +A 15 0A 43 -2,-0.4 2,-0.4 10,-0.2 10,-0.2 -0.982 13.5 177.5-131.8 121.7 27.5 17.9 21.9 6 10 A E E -A 14 0A 100 8,-2.4 8,-2.9 -2,-0.4 2,-0.3 -0.971 32.1-113.5-130.6 140.7 25.3 18.8 24.9 7 11 A K E +A 13 0A 167 -2,-0.4 6,-0.3 6,-0.2 3,-0.1 -0.527 33.4 170.0 -73.8 125.9 22.9 16.7 27.0 8 12 A L E - 0 0 45 4,-3.4 2,-0.3 1,-0.5 5,-0.2 0.765 66.3 -26.7-102.0 -40.7 19.3 17.9 26.6 9 13 A D E > S-A 12 0A 69 3,-2.3 3,-2.7 0, 0.0 -1,-0.5 -0.935 96.8 -45.7-159.6 173.0 17.4 15.0 28.3 10 14 A E T 3 S- 0 0 142 1,-0.3 3,-0.1 -2,-0.3 25,-0.1 -0.336 131.7 -5.1 -48.0 114.1 17.9 11.3 29.0 11 15 A G T 3 S+ 0 0 16 -2,-0.2 24,-2.9 1,-0.1 2,-0.4 0.717 114.2 106.2 67.4 21.8 19.1 9.9 25.7 12 16 A V E < +AB 9 34A 3 -3,-2.7 -4,-3.4 22,-0.2 -3,-2.3 -0.956 43.3 175.7-135.2 118.3 18.6 13.3 23.9 13 17 A Y E -AB 7 33A 46 20,-2.7 20,-2.2 -2,-0.4 2,-0.6 -0.895 24.8-136.0-119.1 146.1 21.6 15.4 22.9 14 18 A V E -AB 6 32A 12 -8,-2.9 -8,-2.4 -2,-0.3 2,-0.5 -0.910 16.5-157.6 -98.0 122.5 21.8 18.6 20.9 15 19 A H E -AB 5 31A 1 16,-2.0 16,-2.3 -2,-0.6 2,-0.5 -0.882 7.8-162.8 -94.5 133.5 24.6 18.7 18.4 16 20 A T E +AB 4 30A 7 -12,-2.3 -12,-2.2 -2,-0.5 2,-0.3 -0.976 11.1 176.1-117.6 119.7 25.7 22.2 17.4 17 21 A S E - B 0 29A 1 12,-2.3 12,-2.3 -2,-0.5 2,-0.4 -0.748 19.9-131.2-114.8 171.3 27.7 22.8 14.3 18 22 A F E - B 0 28A 60 -17,-0.3 2,-0.4 -2,-0.3 8,-0.1 -0.958 15.3-169.0-134.7 138.2 28.8 26.2 12.9 19 23 A E E - B 0 27A 84 8,-1.9 8,-2.8 -2,-0.4 2,-0.5 -0.969 21.0-133.8-122.3 140.9 28.7 28.1 9.6 20 24 A E E - B 0 26A 109 -2,-0.4 2,-0.6 6,-0.2 6,-0.2 -0.792 10.8-158.0 -91.9 129.5 30.5 31.3 8.8 21 25 A V E >> - B 0 25A 30 4,-2.3 3,-1.8 -2,-0.5 4,-1.3 -0.971 13.5-146.5-108.2 118.6 28.4 33.8 7.1 22 26 A N T 34 S+ 0 0 150 -2,-0.6 -1,-0.1 1,-0.3 4,-0.1 0.836 93.4 43.0 -60.8 -42.9 31.0 36.0 5.5 23 27 A G T 34 S+ 0 0 74 2,-0.1 -1,-0.3 -3,-0.1 -3,-0.0 0.233 132.3 18.2 -89.5 8.6 29.2 39.3 5.7 24 28 A W T <4 S- 0 0 93 -3,-1.8 2,-0.3 1,-0.1 -2,-0.2 0.455 99.4-104.3-138.1 -65.6 28.1 38.6 9.3 25 29 A G E < -B 21 0A 16 -4,-1.3 -4,-2.3 -6,-0.1 2,-0.3 -0.965 55.6 -23.4 156.6-164.5 29.8 36.0 11.4 26 30 A V E -B 20 0A 63 -2,-0.3 -6,-0.2 -6,-0.2 -8,-0.0 -0.577 49.3-163.7 -84.3 133.3 29.4 32.6 12.8 27 31 A V E -B 19 0A 6 -8,-2.8 -8,-1.9 -2,-0.3 2,-0.2 -0.957 13.9-132.8-118.6 131.5 26.0 31.0 13.2 28 32 A P E -B 18 0A 43 0, 0.0 2,-0.4 0, 0.0 -10,-0.2 -0.573 15.4-161.6 -78.0 144.7 25.1 27.9 15.3 29 33 A K E -B 17 0A 2 -12,-2.3 -12,-2.3 -2,-0.2 2,-0.4 -0.991 8.3-152.0-129.0 121.6 22.9 25.1 13.9 30 34 A H E +B 16 0A 27 162,-3.1 2,-0.3 -2,-0.4 -14,-0.2 -0.757 23.2 156.4 -94.4 136.2 21.2 22.6 16.3 31 35 A G E -B 15 0A 0 -16,-2.3 -16,-2.0 -2,-0.4 2,-0.3 -0.807 32.3-115.9-133.3-175.9 20.2 19.1 15.5 32 36 A L E -BC 14 43A 0 11,-2.3 11,-2.9 -2,-0.3 2,-0.5 -0.863 7.4-153.5-120.6 153.3 19.7 16.1 17.8 33 37 A V E -BC 13 42A 0 -20,-2.2 -20,-2.7 -2,-0.3 2,-0.5 -0.999 23.6-164.7-112.6 127.5 21.1 12.8 18.5 34 38 A V E -BC 12 41A 9 7,-2.7 7,-2.4 -2,-0.5 2,-0.6 -0.955 8.5-148.3-114.5 125.6 18.4 10.6 20.0 35 39 A L E + C 0 40A 36 -24,-2.9 2,-0.4 -2,-0.5 5,-0.2 -0.824 19.5 174.4 -95.5 119.9 19.3 7.3 21.7 36 40 A V E > S- C 0 39A 12 3,-2.9 3,-0.8 -2,-0.6 -2,-0.0 -0.994 74.8 -16.8-124.3 120.8 16.8 4.5 21.4 37 41 A N T 3 S- 0 0 133 -2,-0.4 -1,-0.1 1,-0.3 3,-0.1 0.867 127.7 -54.1 51.5 45.2 17.7 1.1 22.8 38 42 A A T 3 S+ 0 0 54 1,-0.2 27,-0.5 26,-0.1 2,-0.3 0.844 118.1 113.2 58.0 35.5 21.4 2.1 22.9 39 43 A E E < -Cd 36 65A 60 -3,-0.8 -3,-2.9 25,-0.2 2,-0.4 -0.987 62.4-124.5-137.5 147.5 21.3 3.0 19.2 40 44 A A E -Cd 35 66A 0 25,-2.9 27,-3.1 -2,-0.3 28,-1.0 -0.775 18.9-173.5-107.6 133.2 21.7 6.4 17.7 41 45 A Y E -Cd 34 68A 34 -7,-2.4 -7,-2.7 -2,-0.4 2,-0.5 -0.982 19.2-139.5-117.6 131.4 19.4 8.4 15.4 42 46 A L E -Cd 33 69A 0 26,-2.7 28,-2.5 -2,-0.4 2,-0.7 -0.764 7.0-161.5 -88.2 130.6 20.5 11.7 13.9 43 47 A I E S-Cd 32 70A 0 -11,-2.9 -11,-2.3 -2,-0.5 28,-0.2 -0.928 76.5 -11.5-109.7 97.8 17.9 14.5 13.7 44 48 A D S S- 0 0 0 26,-2.8 -1,-0.2 -2,-0.7 35,-0.1 0.224 81.9-116.9 80.1 149.6 19.4 16.8 11.1 45 49 A T B -g 79 0B 0 33,-1.1 35,-0.6 -3,-0.1 36,-0.2 -0.972 28.8-101.0-123.9 136.1 23.0 16.4 10.0 46 50 A P - 0 0 0 0, 0.0 6,-0.1 0, 0.0 35,-0.1 -0.050 39.2-104.7 -53.2 155.7 25.9 18.9 10.5 47 51 A F S S+ 0 0 31 33,-0.2 2,-0.2 30,-0.1 31,-0.1 0.814 96.0 50.6 -52.1 -39.7 26.8 21.1 7.4 48 52 A T S > S- 0 0 66 1,-0.1 4,-2.0 29,-0.1 5,-0.2 -0.704 76.1-125.9-112.7 154.9 30.0 19.2 6.6 49 53 A A H > S+ 0 0 49 -2,-0.2 4,-2.8 1,-0.2 5,-0.2 0.872 111.6 55.8 -54.7 -42.2 31.2 15.7 6.0 50 54 A K H > S+ 0 0 175 1,-0.2 4,-2.2 2,-0.2 -1,-0.2 0.900 109.5 43.1 -65.8 -42.3 33.9 16.2 8.7 51 55 A D H > S+ 0 0 24 2,-0.2 4,-2.6 1,-0.2 -1,-0.2 0.847 114.2 51.5 -71.6 -35.9 31.5 17.2 11.4 52 56 A T H X S+ 0 0 0 -4,-2.0 4,-2.8 2,-0.2 5,-0.2 0.948 111.8 46.7 -61.8 -50.5 29.1 14.4 10.5 53 57 A E H X S+ 0 0 77 -4,-2.8 4,-2.7 2,-0.2 5,-0.3 0.924 113.2 50.0 -55.2 -45.1 31.9 11.9 10.6 54 58 A K H X S+ 0 0 87 -4,-2.2 4,-2.0 -5,-0.2 -2,-0.2 0.938 113.8 44.3 -62.1 -46.8 33.0 13.3 13.9 55 59 A L H X S+ 0 0 0 -4,-2.6 4,-2.0 2,-0.2 -2,-0.2 0.928 116.8 45.5 -59.2 -50.9 29.5 13.2 15.4 56 60 A V H X S+ 0 0 0 -4,-2.8 4,-3.0 1,-0.2 3,-0.2 0.966 114.8 45.3 -62.6 -56.3 28.8 9.7 14.1 57 61 A T H X S+ 0 0 40 -4,-2.7 4,-2.6 -5,-0.2 5,-0.3 0.845 106.6 62.4 -56.2 -36.8 32.1 8.2 15.1 58 62 A W H X S+ 0 0 117 -4,-2.0 4,-0.8 -5,-0.3 -1,-0.2 0.950 114.5 32.6 -56.0 -51.0 31.8 9.9 18.5 59 63 A F H <>S+ 0 0 15 -4,-2.0 5,-1.9 -3,-0.2 3,-0.3 0.936 119.2 52.2 -70.6 -44.5 28.7 7.8 19.2 60 64 A V H ><5S+ 0 0 54 -4,-3.0 3,-2.1 1,-0.2 -3,-0.2 0.914 105.0 52.4 -61.3 -49.3 29.6 4.7 17.3 61 65 A E H 3<5S+ 0 0 120 -4,-2.6 -1,-0.2 1,-0.3 -2,-0.1 0.821 106.0 56.2 -60.4 -30.7 33.1 4.0 18.9 62 66 A R T 3<5S- 0 0 129 -4,-0.8 -1,-0.3 -3,-0.3 -2,-0.2 0.320 130.2 -91.1 -86.0 6.9 31.5 4.3 22.4 63 67 A G T < 5S+ 0 0 50 -3,-2.1 2,-0.7 1,-0.1 -3,-0.2 0.537 91.7 115.4 103.8 8.2 29.1 1.5 21.5 64 68 A Y < - 0 0 93 -5,-1.9 -25,-0.2 -25,-0.1 -2,-0.1 -0.875 56.5-145.2-111.9 97.1 25.9 3.2 20.2 65 69 A K E -d 39 0A 141 -2,-0.7 -25,-2.9 -27,-0.5 2,-0.6 -0.294 18.6-115.2 -62.7 139.5 25.5 2.2 16.5 66 70 A I E +d 40 0A 19 -27,-0.2 -25,-0.2 1,-0.2 -1,-0.1 -0.686 33.2 179.7 -78.5 118.2 24.1 4.8 14.1 67 71 A K E - 0 0 85 -27,-3.1 2,-0.3 -2,-0.6 -26,-0.2 0.785 55.5 -50.0 -92.6 -30.3 20.8 3.5 12.9 68 72 A G E -d 41 0A 0 -28,-1.0 -26,-2.7 22,-0.1 2,-0.4 -0.973 42.7-117.0 175.8 176.3 19.9 6.4 10.7 69 73 A S E -de 42 92A 0 22,-1.6 24,-2.3 -2,-0.3 2,-0.5 -0.988 13.4-157.4-132.3 145.0 19.4 10.1 10.1 70 74 A I E -de 43 93A 0 -28,-2.5 -26,-2.8 -2,-0.4 2,-0.5 -0.989 10.6-149.5-120.1 129.1 16.4 12.2 9.3 71 75 A S - 0 0 0 22,-2.2 24,-0.4 -2,-0.5 8,-0.1 -0.884 2.2-154.2 -99.1 130.9 16.7 15.5 7.6 72 76 A S S S- 0 0 2 -2,-0.5 68,-2.4 6,-0.1 2,-0.3 0.653 73.4 -6.2 -82.4 -20.9 14.0 18.1 8.5 73 77 A H S S- 0 0 2 2,-0.2 -1,-0.1 66,-0.2 5,-0.1 -0.963 75.2 -97.9-163.0 174.7 14.3 20.1 5.3 74 78 A F S S+ 0 0 16 -2,-0.3 5,-0.1 4,-0.1 -2,-0.0 0.640 79.5 111.3 -77.7 -16.3 16.4 20.4 2.1 75 79 A H S >> S- 0 0 33 1,-0.1 3,-2.5 3,-0.1 4,-1.1 -0.239 79.5-115.4 -58.9 147.2 18.8 23.3 3.2 76 80 A S H 3> S+ 0 0 64 1,-0.3 4,-2.1 2,-0.2 5,-0.1 0.717 111.5 69.8 -62.2 -19.9 22.4 22.2 3.7 77 81 A D H 34 S+ 0 0 18 1,-0.2 -1,-0.3 2,-0.2 -30,-0.1 0.668 113.1 31.9 -70.7 -13.0 22.3 23.0 7.4 78 82 A S H <4 S+ 0 0 0 -3,-2.5 -33,-1.1 -34,-0.1 -2,-0.2 0.583 131.7 31.4-109.6 -19.5 20.0 20.0 7.7 79 83 A T H >< S+g 45 0B 13 -4,-1.1 3,-2.0 -35,-0.1 4,-0.4 0.368 78.3 108.7-126.1 0.3 21.3 17.8 4.9 80 84 A G T 3< S+ 0 0 22 -4,-2.1 4,-0.3 -35,-0.6 3,-0.2 0.727 82.5 50.9 -56.3 -25.4 25.1 18.5 4.7 81 85 A G T 3> S+ 0 0 0 -36,-0.2 4,-2.6 1,-0.2 -1,-0.3 0.460 81.7 92.7 -93.7 -3.5 26.0 15.1 6.1 82 86 A I H <> S+ 0 0 1 -3,-2.0 4,-2.9 2,-0.2 5,-0.3 0.913 82.9 54.9 -58.5 -44.3 23.8 13.0 3.8 83 87 A E H > S+ 0 0 124 -4,-0.4 4,-2.2 -3,-0.2 -1,-0.2 0.964 112.5 42.0 -50.0 -57.5 26.7 12.4 1.3 84 88 A W H > S+ 0 0 45 -4,-0.3 4,-1.3 2,-0.2 -2,-0.2 0.925 114.7 51.0 -57.3 -47.6 29.0 11.0 4.0 85 89 A L H ><>S+ 0 0 0 -4,-2.6 5,-2.8 1,-0.2 3,-0.7 0.950 112.9 45.3 -56.9 -52.0 26.2 8.9 5.6 86 90 A N H ><5S+ 0 0 37 -4,-2.9 3,-2.0 1,-0.2 -1,-0.2 0.864 106.6 59.9 -57.2 -37.9 25.2 7.4 2.3 87 91 A S H 3<5S+ 0 0 87 -4,-2.2 -1,-0.2 -5,-0.3 -2,-0.2 0.783 110.3 42.7 -66.8 -25.3 28.9 6.8 1.5 88 92 A R T <<5S- 0 0 133 -4,-1.3 -1,-0.3 -3,-0.7 -2,-0.2 0.241 117.1-115.4 -98.3 12.3 29.0 4.6 4.6 89 93 A S T < 5 + 0 0 110 -3,-2.0 -3,-0.2 1,-0.2 -2,-0.1 0.821 62.1 153.3 57.4 31.0 25.7 3.0 3.8 90 94 A I < - 0 0 13 -5,-2.8 -1,-0.2 -6,-0.2 -2,-0.1 -0.829 54.9-104.7 -87.5 126.5 24.1 4.5 6.9 91 95 A P - 0 0 49 0, 0.0 -22,-1.6 0, 0.0 2,-0.4 -0.280 39.7-166.2 -57.8 129.6 20.4 4.8 6.3 92 96 A T E -e 69 0A 0 -24,-0.2 20,-2.4 17,-0.1 2,-0.4 -0.915 2.1-164.8-116.9 146.5 19.3 8.4 5.5 93 97 A Y E +ef 70 112A 47 -24,-2.3 -22,-2.2 -2,-0.4 2,-0.3 -0.962 18.3 150.0-131.8 144.4 15.7 9.6 5.5 94 98 A A E - f 0 113A 0 18,-1.9 20,-0.6 -2,-0.4 -22,-0.1 -0.941 47.5 -90.1-164.1 160.0 13.9 12.7 4.2 95 99 A S E > - f 0 114A 7 -24,-0.4 4,-2.4 -2,-0.3 20,-0.2 -0.191 38.9-109.3 -68.6 163.5 10.4 13.3 2.9 96 100 A E H > S+ 0 0 111 18,-2.5 4,-2.4 1,-0.2 5,-0.2 0.885 121.7 53.5 -56.8 -41.8 9.6 13.0 -0.8 97 101 A L H > S+ 0 0 80 17,-0.3 4,-2.4 2,-0.2 -1,-0.2 0.927 108.8 48.8 -59.5 -42.9 9.3 16.8 -1.0 98 102 A T H > S+ 0 0 0 40,-0.2 4,-2.7 1,-0.2 -2,-0.2 0.943 112.0 48.4 -63.7 -46.1 12.7 17.2 0.5 99 103 A N H X S+ 0 0 14 -4,-2.4 4,-2.8 1,-0.2 -1,-0.2 0.878 109.2 53.3 -62.3 -37.8 14.3 14.7 -1.9 100 104 A E H X S+ 0 0 97 -4,-2.4 4,-2.4 2,-0.2 -1,-0.2 0.939 111.1 46.0 -62.5 -47.3 12.6 16.4 -4.9 101 105 A L H X S+ 0 0 39 -4,-2.4 4,-1.9 2,-0.2 -2,-0.2 0.916 112.4 51.0 -59.9 -44.3 14.1 19.8 -3.8 102 106 A L H <>S+ 0 0 0 -4,-2.7 5,-2.9 1,-0.2 -2,-0.2 0.931 110.5 49.9 -55.9 -48.9 17.6 18.1 -3.2 103 107 A K H ><5S+ 0 0 146 -4,-2.8 3,-1.5 1,-0.2 -2,-0.2 0.918 110.7 48.4 -56.4 -46.1 17.4 16.6 -6.7 104 108 A K H 3<5S+ 0 0 169 -4,-2.4 -1,-0.2 1,-0.3 -2,-0.2 0.844 110.9 51.8 -64.3 -31.4 16.5 19.9 -8.4 105 109 A D T 3<5S- 0 0 90 -4,-1.9 -1,-0.3 -5,-0.2 -2,-0.2 0.282 118.1-111.6 -88.3 8.5 19.3 21.6 -6.5 106 110 A G T < 5S+ 0 0 69 -3,-1.5 2,-0.3 1,-0.2 -3,-0.2 0.912 71.2 141.0 57.9 43.4 21.8 19.0 -7.7 107 111 A K < - 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