==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=1-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 26-JUL-06 2HU6 . COMPND 2 MOLECULE: MACROPHAGE METALLOELASTASE; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR C.MANNINO,M.NIEVO,F.MACHETTI,A.PAPAKYRIAKOU,V.CALDERONE, . 158 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 8366.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 85 53.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 17 10.8 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 4 2.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 10 6.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 15 9.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 32 20.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 1 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 106 A G 0 0 107 0, 0.0 120,-0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0-167.2 9.1 13.0 2.5 2 107 A P + 0 0 71 0, 0.0 2,-0.3 0, 0.0 81,-0.1 -0.257 360.0 179.3 -65.4 142.0 7.4 14.3 5.7 3 108 A V - 0 0 33 78,-0.1 2,-0.3 79,-0.0 117,-0.1 -0.941 38.8 -92.8-132.3 161.0 9.0 13.8 9.1 4 109 A W - 0 0 25 115,-0.3 5,-0.0 -2,-0.3 115,-0.0 -0.582 29.5-154.3 -69.8 135.7 8.1 14.9 12.6 5 110 A R S S+ 0 0 212 -2,-0.3 2,-0.3 2,-0.0 -1,-0.1 -0.071 71.1 57.6-104.4 30.2 9.7 18.2 13.4 6 111 A K S S- 0 0 96 1,-0.1 -2,-0.1 0, 0.0 3,-0.0 -0.959 72.9-133.1-155.0 161.0 9.7 17.7 17.2 7 112 A H S S+ 0 0 111 -2,-0.3 36,-2.7 35,-0.1 2,-0.7 0.750 84.8 73.8 -97.8 -26.4 11.2 15.1 19.6 8 113 A Y E -a 43 0A 182 34,-0.2 2,-0.4 36,-0.1 36,-0.2 -0.828 63.5-179.6 -93.6 112.6 8.3 14.4 22.0 9 114 A I E -a 44 0A 1 34,-3.2 36,-1.9 -2,-0.7 2,-0.3 -0.931 11.1-152.8-116.0 135.0 5.7 12.2 20.1 10 115 A T E -a 45 0A 36 -2,-0.4 44,-2.4 34,-0.2 43,-0.5 -0.795 8.7-171.3-106.8 149.9 2.4 10.9 21.6 11 116 A Y E -ab 46 54A 5 34,-2.3 36,-2.8 -2,-0.3 2,-0.4 -0.956 3.9-163.2-132.3 155.9 0.4 7.9 20.7 12 117 A R E - b 0 55A 59 42,-2.0 44,-3.1 -2,-0.3 2,-0.9 -0.999 20.3-133.9-137.7 135.8 -3.0 6.7 21.8 13 118 A I E - b 0 56A 12 34,-0.4 44,-0.2 -2,-0.4 3,-0.1 -0.830 19.8-168.3 -91.1 106.1 -4.6 3.3 21.5 14 119 A N - 0 0 70 42,-2.6 2,-0.3 -2,-0.9 -1,-0.2 0.870 66.2 -14.6 -60.9 -43.6 -8.0 4.0 20.1 15 120 A N - 0 0 52 41,-0.7 2,-0.4 -3,-0.1 -1,-0.2 -0.958 69.6-113.9-159.3 164.3 -9.4 0.5 20.8 16 121 A Y - 0 0 60 -2,-0.3 6,-0.1 -3,-0.1 41,-0.0 -0.906 22.3-120.1-117.3 133.8 -8.1 -2.9 21.6 17 122 A T > - 0 0 0 -2,-0.4 3,-1.0 1,-0.1 8,-0.1 -0.416 14.9-140.9 -62.3 137.8 -8.2 -6.2 19.7 18 123 A P T 3 S+ 0 0 102 0, 0.0 -1,-0.1 0, 0.0 4,-0.1 0.490 92.6 82.4 -76.1 -1.1 -10.2 -8.9 21.4 19 124 A D T 3 S+ 0 0 38 77,-0.1 2,-0.3 2,-0.1 -2,-0.0 0.657 96.2 33.3 -72.3 -19.5 -7.4 -11.3 20.2 20 125 A M S < S- 0 0 16 -3,-1.0 2,-0.2 79,-0.1 79,-0.1 -0.880 91.3 -87.9-136.6 161.9 -5.1 -10.4 23.0 21 126 A N >> - 0 0 100 -2,-0.3 4,-1.8 1,-0.1 3,-0.6 -0.516 42.1-122.1 -65.6 140.7 -4.9 -9.5 26.7 22 127 A R H 3> S+ 0 0 140 1,-0.3 4,-2.3 2,-0.2 3,-0.3 0.904 112.2 51.2 -51.5 -48.1 -5.1 -5.7 27.1 23 128 A E H 3> S+ 0 0 141 1,-0.2 4,-2.2 2,-0.2 -1,-0.3 0.817 107.4 54.2 -63.5 -29.9 -1.7 -5.5 28.9 24 129 A D H <> S+ 0 0 45 -3,-0.6 4,-2.4 2,-0.2 -1,-0.2 0.833 106.8 50.6 -74.1 -33.4 -0.1 -7.5 26.1 25 130 A V H X S+ 0 0 0 -4,-1.8 4,-2.4 -3,-0.3 5,-0.3 0.954 112.0 48.2 -64.0 -49.2 -1.4 -5.0 23.4 26 131 A D H X S+ 0 0 49 -4,-2.3 4,-2.6 1,-0.2 -2,-0.2 0.921 114.8 45.3 -55.1 -47.2 0.0 -2.1 25.5 27 132 A Y H X S+ 0 0 135 -4,-2.2 4,-2.9 2,-0.2 5,-0.2 0.904 111.1 51.3 -69.0 -42.1 3.4 -3.9 25.9 28 133 A A H X S+ 0 0 11 -4,-2.4 4,-1.9 2,-0.2 -1,-0.2 0.926 114.6 43.8 -59.2 -45.0 3.7 -4.9 22.3 29 134 A I H X S+ 0 0 1 -4,-2.4 4,-2.2 2,-0.2 -2,-0.2 0.926 113.5 50.8 -68.6 -44.3 3.0 -1.4 21.1 30 135 A R H X S+ 0 0 140 -4,-2.6 4,-2.2 -5,-0.3 -2,-0.2 0.934 111.6 47.9 -56.6 -48.1 5.3 0.2 23.7 31 136 A K H X S+ 0 0 77 -4,-2.9 4,-1.7 1,-0.2 -1,-0.2 0.869 108.6 54.7 -63.2 -36.7 8.2 -2.2 22.7 32 137 A A H X S+ 0 0 0 -4,-1.9 4,-0.9 -5,-0.2 -1,-0.2 0.911 109.1 47.2 -65.7 -40.7 7.6 -1.4 19.0 33 138 A F H >X S+ 0 0 3 -4,-2.2 4,-2.3 1,-0.2 3,-0.7 0.905 107.5 57.8 -61.6 -41.5 8.0 2.3 19.7 34 139 A Q H 3X S+ 0 0 58 -4,-2.2 4,-2.0 1,-0.2 -2,-0.2 0.842 95.4 64.4 -59.6 -35.5 11.1 1.6 21.8 35 140 A V H 3< S+ 0 0 17 -4,-1.7 4,-0.3 1,-0.2 -1,-0.2 0.908 111.0 37.0 -51.9 -43.7 12.7 -0.1 18.8 36 141 A W H X< S+ 0 0 0 -4,-0.9 3,-1.2 -3,-0.7 4,-0.3 0.848 112.5 54.5 -83.6 -35.4 12.7 3.3 17.0 37 142 A S H >< S+ 0 0 32 -4,-2.3 3,-0.6 1,-0.2 -1,-0.2 0.769 98.7 68.3 -68.2 -21.3 13.5 5.5 20.0 38 143 A N T 3< S+ 0 0 128 -4,-2.0 -1,-0.2 -5,-0.2 -2,-0.2 0.737 111.5 30.3 -61.5 -26.3 16.6 3.3 20.5 39 144 A V T < S+ 0 0 31 -3,-1.2 -1,-0.2 -4,-0.3 -2,-0.2 0.205 120.8 47.8-125.4 12.6 18.1 4.6 17.3 40 145 A T S < S- 0 0 19 -3,-0.6 114,-0.1 -4,-0.3 118,-0.1 -0.886 84.7-108.4-141.2 171.0 16.7 8.2 17.1 41 146 A P S S+ 0 0 60 0, 0.0 -4,-0.1 0, 0.0 -3,-0.1 0.393 78.6 123.4 -81.3 6.0 16.3 11.2 19.4 42 147 A L - 0 0 2 -6,-0.2 2,-0.4 -34,-0.1 -2,-0.2 -0.323 46.5-159.7 -72.3 147.7 12.5 10.6 19.5 43 148 A K E -a 8 0A 128 -36,-2.7 -34,-3.2 2,-0.0 2,-0.4 -0.999 7.7-157.4-125.8 130.7 10.6 10.0 22.7 44 149 A F E -a 9 0A 32 -2,-0.4 2,-0.4 -36,-0.2 -34,-0.2 -0.910 10.2-178.1-114.6 135.6 7.2 8.3 22.7 45 150 A S E -a 10 0A 64 -36,-1.9 -34,-2.3 -2,-0.4 2,-0.4 -0.999 22.9-131.9-134.1 133.5 4.5 8.6 25.3 46 151 A K E -a 11 0A 70 -2,-0.4 2,-0.3 -36,-0.2 -34,-0.2 -0.683 24.1-164.6 -80.5 130.6 1.1 6.9 25.5 47 152 A I - 0 0 48 -36,-2.8 -34,-0.4 -2,-0.4 3,-0.1 -0.877 15.7-152.0-116.8 153.3 -1.8 9.2 26.3 48 153 A N S S+ 0 0 122 -2,-0.3 2,-0.3 1,-0.2 -1,-0.1 0.731 75.3 18.2 -96.5 -27.6 -5.3 8.2 27.4 49 154 A T S S+ 0 0 116 2,-0.1 -1,-0.2 -37,-0.0 2,-0.0 -0.927 96.5 27.4-140.5 161.5 -7.4 11.0 26.1 50 155 A G S S- 0 0 54 -2,-0.3 2,-0.6 -3,-0.1 -3,-0.1 -0.221 96.1 -21.3 85.7-170.0 -7.2 13.8 23.5 51 156 A M - 0 0 179 -2,-0.0 2,-0.2 4,-0.0 -2,-0.1 -0.668 59.6-173.5 -86.0 114.5 -5.3 14.3 20.2 52 157 A A - 0 0 14 -2,-0.6 3,-0.2 1,-0.1 -41,-0.2 -0.645 31.7-127.3 -96.9 159.9 -2.2 12.1 19.8 53 158 A D S S+ 0 0 28 -43,-0.5 2,-0.6 1,-0.3 -42,-0.2 0.929 102.9 35.4 -66.6 -46.4 0.3 12.3 17.0 54 159 A I E S-b 11 0A 0 -44,-2.4 -42,-2.0 35,-0.1 2,-0.6 -0.932 73.6-164.0-116.6 109.3 -0.1 8.6 16.3 55 160 A L E -b 12 0A 35 -2,-0.6 35,-2.4 -44,-0.2 2,-0.6 -0.845 9.6-151.1 -92.1 124.4 -3.5 7.0 16.7 56 161 A V E -bc 13 90A 2 -44,-3.1 -42,-2.6 -2,-0.6 -41,-0.7 -0.868 22.2-179.9 -96.6 121.7 -3.4 3.2 16.9 57 162 A V E - c 0 91A 19 33,-2.7 35,-3.1 -2,-0.6 2,-0.5 -0.959 24.9-155.0-127.8 138.5 -6.6 1.6 15.6 58 163 A F E + c 0 92A 7 -2,-0.4 2,-0.3 33,-0.2 35,-0.2 -0.970 37.7 145.7-106.9 126.3 -7.9 -2.0 15.2 59 164 A A E - c 0 93A 18 33,-2.4 35,-2.6 -2,-0.5 36,-0.4 -0.983 34.4-138.9-154.8 160.3 -10.5 -2.2 12.4 60 165 A R - 0 0 135 -2,-0.3 33,-0.0 33,-0.2 -2,-0.0 -0.887 60.7 -19.9-123.2 158.0 -11.8 -4.4 9.7 61 166 A G S S+ 0 0 24 -2,-0.3 8,-2.3 7,-0.1 2,-0.4 -0.146 122.9 7.6 52.6-139.3 -13.0 -3.9 6.1 62 167 A A + 0 0 92 6,-0.3 -2,-0.2 1,-0.1 6,-0.1 -0.621 68.5 167.0 -74.4 127.3 -14.0 -0.3 5.3 63 168 A H - 0 0 44 -2,-0.4 -1,-0.1 -4,-0.1 -2,-0.1 0.058 59.4 -82.8-140.4 26.3 -13.0 1.9 8.2 64 169 A G S S+ 0 0 85 1,-0.0 -2,-0.1 0, 0.0 4,-0.0 0.515 106.7 84.3 96.7 9.1 -13.3 5.5 7.1 65 170 A D S S- 0 0 23 21,-0.0 -3,-0.0 2,-0.0 -1,-0.0 0.327 94.8-112.7-125.1 7.3 -10.0 6.3 5.3 66 171 A D S S+ 0 0 163 1,-0.1 2,-0.6 0, 0.0 -4,-0.0 0.397 94.8 100.7 75.9 -1.2 -10.6 5.0 1.8 67 172 A H - 0 0 97 -6,-0.1 -1,-0.1 11,-0.0 11,-0.0 -0.650 63.5-164.5-111.4 72.6 -7.9 2.3 2.4 68 173 A A - 0 0 57 -2,-0.6 -6,-0.3 1,-0.1 2,-0.1 -0.177 14.3-122.9 -63.0 145.7 -10.2 -0.7 3.1 69 174 A F - 0 0 14 -8,-2.3 3,-0.1 1,-0.1 -1,-0.1 -0.436 12.1-139.4 -83.3 168.3 -8.9 -4.0 4.6 70 175 A D - 0 0 81 1,-0.5 -1,-0.1 5,-0.4 2,-0.1 0.002 39.1-103.5-125.2 21.2 -9.3 -7.3 2.9 71 176 A G S S- 0 0 20 4,-0.0 -1,-0.5 3,-0.0 24,-0.1 -0.298 79.0 -6.1 78.2-171.1 -10.2 -9.9 5.5 72 177 A K S S+ 0 0 147 23,-0.1 24,-0.2 -3,-0.1 2,-0.1 -0.307 120.1 5.3 -62.0 135.8 -7.8 -12.5 7.0 73 178 A G S S+ 0 0 30 1,-0.1 -3,-0.3 2,-0.1 2,-0.2 -0.331 98.9 64.7 85.2-171.6 -4.4 -12.5 5.3 74 179 A G S S+ 0 0 67 -2,-0.1 2,-0.4 -5,-0.1 -1,-0.1 -0.394 103.9 30.7 62.1-125.2 -3.2 -10.1 2.6 75 180 A I + 0 0 74 -2,-0.2 -5,-0.4 1,-0.2 3,-0.1 -0.549 64.3 178.9 -66.9 122.6 -2.9 -6.6 4.1 76 181 A L - 0 0 32 1,-0.4 17,-2.5 -2,-0.4 2,-0.3 0.764 62.3 -27.2 -93.8 -32.7 -2.1 -6.9 7.8 77 182 A A E -D 92 0A 12 15,-0.3 -1,-0.4 -19,-0.0 2,-0.3 -0.959 54.7-154.9-170.5 164.8 -1.9 -3.3 8.7 78 183 A H E -D 91 0A 32 13,-2.4 13,-3.2 -2,-0.3 2,-0.3 -0.978 6.6-164.2-152.2 162.4 -1.1 0.1 7.2 79 184 A A E -D 90 0A 19 -2,-0.3 2,-0.4 11,-0.2 11,-0.2 -0.989 16.7-124.3-150.1 154.1 0.0 3.5 8.5 80 185 A F - 0 0 36 9,-2.4 8,-0.6 6,-0.3 3,-0.1 -0.792 30.2-112.5-103.8 142.0 0.2 7.1 7.3 81 186 A G - 0 0 33 -2,-0.4 7,-1.2 6,-0.2 8,-0.2 -0.134 56.5 -60.8 -63.7 165.0 3.4 9.2 7.2 82 187 A P S S+ 0 0 9 0, 0.0 2,-0.3 0, 0.0 -1,-0.2 -0.128 85.3 98.7 -50.5 139.1 4.0 12.2 9.5 83 188 A G S S- 0 0 36 4,-0.2 -3,-0.0 -30,-0.1 -79,-0.0 -0.906 70.6 -56.2 162.8 175.3 1.4 15.0 9.2 84 189 A S S > S+ 0 0 118 -2,-0.3 3,-2.3 2,-0.1 2,-0.2 -0.213 100.1 0.7 -69.0 164.2 -1.7 16.5 10.8 85 190 A G T 3 S+ 0 0 62 1,-0.3 -2,-0.1 3,-0.1 4,-0.1 -0.342 141.7 6.9 64.1-121.1 -4.9 14.6 11.3 86 191 A I T > S+ 0 0 96 -2,-0.2 3,-2.3 2,-0.1 -6,-0.3 0.641 101.5 120.5 -71.0 -13.4 -4.6 11.0 10.1 87 192 A G T < S+ 0 0 9 -3,-2.3 -4,-0.2 1,-0.3 -32,-0.2 -0.246 79.9 15.5 -49.6 134.2 -0.9 11.6 9.6 88 193 A G T 3 S+ 0 0 0 -7,-1.2 -1,-0.3 -8,-0.6 30,-0.1 0.139 93.0 138.9 87.4 -21.7 1.1 9.2 11.7 89 194 A D < - 0 0 14 -3,-2.3 -9,-2.4 -8,-0.2 2,-0.5 -0.241 39.0-153.4 -69.1 147.3 -1.9 6.9 12.4 90 195 A A E -cD 56 79A 1 -35,-2.4 -33,-2.7 -11,-0.2 2,-0.5 -0.983 7.1-165.8-124.1 123.4 -1.4 3.1 12.3 91 196 A H E -cD 57 78A 15 -13,-3.2 -13,-2.4 -2,-0.5 2,-0.4 -0.928 3.0-159.6-114.5 131.9 -4.3 0.8 11.5 92 197 A F E -cD 58 77A 1 -35,-3.1 -33,-2.4 -2,-0.5 2,-0.6 -0.919 26.3-116.2-113.5 130.7 -4.3 -3.0 12.2 93 198 A D E > -c 59 0A 0 -17,-2.5 3,-2.0 -2,-0.4 -33,-0.2 -0.522 17.4-157.1 -71.1 113.2 -6.6 -5.3 10.4 94 199 A E T 3 S+ 0 0 15 -35,-2.6 -34,-0.2 -2,-0.6 -1,-0.2 0.700 87.7 74.4 -65.5 -16.6 -8.9 -6.9 13.0 95 200 A D T 3 S+ 0 0 49 -36,-0.4 -1,-0.3 -24,-0.1 2,-0.2 0.620 85.0 80.9 -74.3 -7.9 -9.5 -9.8 10.6 96 201 A E S < S- 0 0 7 -3,-2.0 2,-0.7 -20,-0.2 -77,-0.1 -0.537 89.3-120.7 -81.3 161.5 -6.0 -11.0 11.5 97 202 A F - 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