==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=31-MAY-2013 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER LIGASE/LIGASE INHIBITOR 25-MAR-13 4JV9 . COMPND 2 MOLECULE: E3 UBIQUITIN-PROTEIN LIGASE MDM2; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR X.HUANG,F.GONZALEZ-LOPEZ DE TURISO,D.SUN,R.YOSUP,M.D.BARTBER . 85 1 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 5610.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 60 70.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 13 15.3 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 1 1.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 3 3.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 9 10.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 30 35.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 2.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 0 0 1 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 26 A T 0 0 117 0, 0.0 24,-0.8 0, 0.0 2,-0.4 0.000 360.0 360.0 360.0 108.3 4.0 -15.3 2.4 2 27 A L E -A 24 0A 87 83,-0.3 83,-2.5 22,-0.2 2,-0.3 -0.789 360.0-169.4 -93.5 135.4 7.3 -15.2 0.7 3 28 A V E -AB 23 84A 0 20,-3.2 20,-2.4 -2,-0.4 81,-0.2 -0.852 21.5-137.9-125.9 162.5 10.2 -16.9 2.5 4 29 A R E - B 0 83A 115 79,-2.7 79,-2.4 -2,-0.3 18,-0.2 -0.937 25.7-138.5-122.3 101.4 14.0 -17.0 2.1 5 30 A P E - B 0 82A 12 0, 0.0 77,-0.3 0, 0.0 74,-0.1 -0.316 21.0-115.5 -62.5 138.5 15.4 -20.6 2.6 6 31 A K >> - 0 0 104 75,-2.6 4,-2.4 1,-0.1 3,-1.2 -0.342 41.7 -88.1 -71.0 156.9 18.6 -20.9 4.6 7 32 A P H 3> S+ 0 0 104 0, 0.0 4,-2.7 0, 0.0 5,-0.2 0.790 124.2 48.9 -30.3 -60.5 21.7 -22.2 2.8 8 33 A L H 3> S+ 0 0 85 1,-0.2 4,-1.6 2,-0.2 52,-0.1 0.837 115.2 42.3 -57.3 -39.7 21.1 -25.9 3.4 9 34 A L H <> S+ 0 0 1 -3,-1.2 4,-2.8 2,-0.2 -1,-0.2 0.858 112.3 55.5 -75.8 -35.0 17.5 -25.9 2.2 10 35 A L H X S+ 0 0 30 -4,-2.4 4,-2.8 1,-0.2 5,-0.2 0.933 105.7 52.4 -61.7 -43.4 18.4 -23.7 -0.7 11 36 A K H X S+ 0 0 143 -4,-2.7 4,-1.3 -5,-0.3 -1,-0.2 0.924 111.5 46.2 -58.6 -45.5 21.0 -26.3 -1.7 12 37 A L H < S+ 0 0 0 -4,-1.6 4,-0.3 2,-0.2 -2,-0.2 0.899 112.7 48.7 -66.6 -41.4 18.3 -29.1 -1.6 13 38 A L H ><>S+ 0 0 0 -4,-2.8 5,-1.8 1,-0.2 3,-1.7 0.946 112.3 47.9 -62.7 -47.6 15.7 -27.1 -3.5 14 39 A K H ><5S+ 0 0 99 -4,-2.8 3,-1.6 1,-0.3 -1,-0.2 0.748 98.2 70.4 -65.1 -22.8 18.2 -26.1 -6.2 15 40 A S T 3<5S+ 0 0 75 -4,-1.3 -1,-0.3 1,-0.3 -2,-0.2 0.605 103.7 43.8 -71.0 -9.8 19.4 -29.7 -6.5 16 41 A V T < 5S- 0 0 19 -3,-1.7 -1,-0.3 -4,-0.3 -2,-0.2 -0.009 137.8 -76.3-121.7 28.0 16.0 -30.5 -8.1 17 42 A G T < 5S+ 0 0 49 -3,-1.6 -3,-0.2 1,-0.3 -2,-0.1 0.375 78.1 147.3 100.3 -5.8 15.8 -27.5 -10.4 18 43 A A < + 0 0 5 -5,-1.8 -1,-0.3 -6,-0.1 10,-0.0 -0.344 18.1 178.2 -64.2 146.5 14.9 -24.6 -8.1 19 44 A Q + 0 0 172 -6,-0.0 -1,-0.1 -2,-0.0 2,-0.1 0.618 45.0 76.5-125.1 -19.5 16.4 -21.3 -9.3 20 45 A K - 0 0 87 1,-0.1 3,-0.1 2,-0.1 -6,-0.1 -0.332 60.6-142.4 -93.8 174.8 15.3 -18.4 -7.0 21 46 A D S S+ 0 0 68 1,-0.1 2,-0.4 -2,-0.1 -1,-0.1 0.620 90.4 55.0-103.9 -22.5 16.3 -17.2 -3.6 22 47 A T + 0 0 39 -18,-0.2 2,-0.3 -20,-0.0 -18,-0.2 -0.910 66.9 163.0-117.2 140.3 12.8 -16.3 -2.7 23 48 A Y E -A 3 0A 1 -20,-2.4 -20,-3.2 -2,-0.4 2,-0.3 -0.924 36.9-113.8-146.4 169.5 9.7 -18.5 -2.8 24 49 A T E >> -A 2 0A 51 -2,-0.3 4,-1.8 -22,-0.2 3,-0.5 -0.671 43.1-107.6 -98.7 162.4 6.1 -19.0 -1.6 25 50 A M H 3> S+ 0 0 16 -24,-0.8 4,-2.7 -2,-0.3 5,-0.2 0.866 119.2 58.7 -60.1 -36.2 5.6 -22.0 0.8 26 51 A K H 3> S+ 0 0 171 1,-0.2 4,-1.7 2,-0.2 -1,-0.2 0.861 106.6 47.7 -62.6 -34.6 3.8 -23.9 -1.9 27 52 A E H <> S+ 0 0 55 -3,-0.5 4,-2.3 2,-0.2 5,-0.3 0.868 110.0 52.7 -73.7 -36.0 6.9 -23.7 -4.1 28 53 A V H X S+ 0 0 0 -4,-1.8 4,-3.3 1,-0.2 5,-0.2 0.975 112.3 44.7 -61.3 -52.8 9.1 -24.8 -1.2 29 54 A L H X S+ 0 0 61 -4,-2.7 4,-2.7 1,-0.2 -1,-0.2 0.837 110.2 55.9 -59.5 -36.5 6.9 -27.8 -0.6 30 55 A F H X S+ 0 0 134 -4,-1.7 4,-1.7 -5,-0.2 -1,-0.2 0.942 115.5 36.1 -62.6 -49.3 6.7 -28.6 -4.3 31 56 A Y H X S+ 0 0 50 -4,-2.3 4,-1.5 2,-0.2 -2,-0.2 0.868 115.7 54.4 -71.5 -39.6 10.6 -28.8 -4.6 32 57 A L H X S+ 0 0 7 -4,-3.3 4,-1.6 -5,-0.3 3,-0.3 0.947 112.2 46.0 -58.3 -45.8 11.0 -30.3 -1.2 33 58 A G H X S+ 0 0 26 -4,-2.7 4,-2.3 1,-0.2 -2,-0.2 0.824 108.6 53.2 -66.3 -34.5 8.6 -33.0 -2.3 34 59 A Q H X S+ 0 0 74 -4,-1.7 4,-1.8 1,-0.2 -1,-0.2 0.735 107.7 54.5 -72.1 -22.8 10.2 -33.5 -5.7 35 60 A Y H X S+ 0 0 13 -4,-1.5 4,-2.1 -3,-0.3 -2,-0.2 0.895 110.2 44.4 -74.2 -42.4 13.5 -34.0 -3.8 36 61 A I H X>S+ 0 0 15 -4,-1.6 5,-2.0 2,-0.2 4,-1.6 0.906 117.9 44.6 -65.8 -47.5 12.0 -36.8 -1.6 37 62 A M H <5S+ 0 0 106 -4,-2.3 -2,-0.2 2,-0.2 -1,-0.2 0.868 113.0 50.8 -67.2 -39.8 10.3 -38.4 -4.6 38 63 A T H <5S+ 0 0 92 -4,-1.8 -2,-0.2 1,-0.2 -1,-0.2 0.899 118.5 37.3 -65.6 -43.7 13.4 -38.1 -6.8 39 64 A K H <5S- 0 0 101 -4,-2.1 -2,-0.2 -5,-0.1 -1,-0.2 0.725 104.7-132.7 -81.7 -19.0 15.6 -39.7 -4.2 40 65 A R T <5 + 0 0 165 -4,-1.6 -3,-0.2 -5,-0.2 -4,-0.1 0.973 46.1 159.4 63.5 56.6 12.9 -42.1 -3.1 41 66 A L < + 0 0 23 -5,-2.0 10,-3.8 -6,-0.1 2,-0.1 0.524 46.4 93.6 -85.5 -7.6 13.4 -41.4 0.6 42 67 A Y B S-C 50 0B 31 -6,-0.4 2,-0.4 8,-0.3 8,-0.2 -0.442 85.9-105.1 -84.1 159.6 9.9 -42.8 1.2 43 68 A D - 0 0 40 6,-1.8 6,-0.2 3,-0.8 -2,-0.1 -0.720 18.5-142.1 -86.9 129.9 9.2 -46.4 2.1 44 69 A E S S+ 0 0 113 -2,-0.4 3,-0.4 1,-0.2 -1,-0.1 0.860 103.1 39.0 -59.1 -38.7 7.7 -48.5 -0.7 45 70 A K S S+ 0 0 197 1,-0.3 2,-0.6 2,-0.0 -1,-0.2 0.906 128.6 31.3 -80.4 -41.9 5.4 -50.3 1.7 46 71 A Q S > S- 0 0 105 1,-0.1 3,-2.2 3,-0.1 -3,-0.8 -0.706 75.4-178.7-117.8 79.3 4.5 -47.3 3.9 47 72 A Q T 3 S+ 0 0 123 -2,-0.6 -1,-0.1 -3,-0.4 -3,-0.1 0.451 74.3 61.2 -59.8 -6.1 4.7 -44.5 1.4 48 73 A H T 3 S+ 0 0 52 -6,-0.1 20,-2.6 19,-0.1 2,-0.4 0.590 89.0 90.1 -95.7 -11.3 3.9 -41.7 3.7 49 74 A I E < - D 0 67B 27 -3,-2.2 -6,-1.8 -6,-0.2 2,-0.5 -0.693 63.4-157.8 -89.4 132.5 7.0 -42.5 5.8 50 75 A V E -CD 42 66B 1 16,-3.1 16,-1.6 -2,-0.4 2,-0.6 -0.933 7.4-159.4-117.5 130.2 10.3 -40.8 4.9 51 76 A Y E + D 0 65B 106 -10,-3.8 14,-0.2 -2,-0.5 7,-0.1 -0.935 24.8 156.0-107.7 115.3 13.8 -42.1 5.8 52 77 A C > + 0 0 1 12,-2.0 3,-1.7 -2,-0.6 6,-0.7 0.038 16.7 146.1-128.4 23.8 16.3 -39.3 5.7 53 78 A S T 3 S+ 0 0 92 11,-0.7 3,-0.1 1,-0.3 4,-0.1 -0.445 78.3 7.3 -67.0 134.1 19.0 -40.6 7.9 54 79 A N T 3 S+ 0 0 163 1,-0.3 -1,-0.3 -2,-0.2 2,-0.2 0.691 110.3 119.3 66.4 20.1 22.5 -39.5 6.8 55 80 A D S <> S- 0 0 17 -3,-1.7 4,-2.1 1,-0.1 -1,-0.3 -0.726 80.9-112.9-112.2 164.7 20.9 -37.3 4.2 56 81 A L H > S+ 0 0 31 -2,-0.2 4,-2.5 1,-0.2 5,-0.1 0.867 121.1 52.0 -59.6 -36.7 20.9 -33.6 3.6 57 82 A L H > S+ 0 0 0 2,-0.2 4,-2.8 1,-0.2 6,-0.3 0.851 106.0 52.4 -69.9 -36.0 17.2 -33.6 4.5 58 83 A G H > S+ 0 0 8 -6,-0.7 4,-1.6 2,-0.2 5,-0.4 0.893 111.0 48.6 -66.1 -38.3 17.9 -35.4 7.8 59 84 A D H < S+ 0 0 109 -4,-2.1 -2,-0.2 2,-0.2 -1,-0.2 0.943 113.7 47.4 -63.8 -48.5 20.5 -32.7 8.5 60 85 A L H < S+ 0 0 14 -4,-2.5 -2,-0.2 1,-0.2 -1,-0.2 0.935 120.4 34.8 -54.6 -57.3 18.0 -30.0 7.7 61 86 A F H < S- 0 0 8 -4,-2.8 -1,-0.2 2,-0.2 -2,-0.2 0.608 97.4-132.7 -77.4 -18.8 15.1 -31.3 9.7 62 87 A G S < S+ 0 0 66 -4,-1.6 -3,-0.1 -5,-0.3 -4,-0.1 0.605 72.3 101.4 74.1 10.4 17.2 -32.7 12.6 63 88 A V - 0 0 44 -5,-0.4 -1,-0.2 -6,-0.3 -2,-0.2 -0.883 68.7-139.5-125.3 157.2 15.2 -36.0 12.4 64 89 A P S S- 0 0 83 0, 0.0 -12,-2.0 0, 0.0 -11,-0.7 0.686 87.2 -0.4 -87.4 -18.0 16.0 -39.5 11.0 65 90 A S E +D 51 0B 54 -14,-0.2 2,-0.3 -13,-0.2 -14,-0.2 -0.978 62.9 176.7-163.7 156.7 12.5 -40.1 9.7 66 91 A F E -D 50 0B 23 -16,-1.6 -16,-3.1 -2,-0.3 2,-0.5 -0.976 27.8-113.1-159.9 164.2 9.1 -38.4 9.5 67 92 A S E > -D 49 0B 15 -2,-0.3 3,-2.0 -18,-0.2 -18,-0.2 -0.907 12.0-143.1-108.8 130.8 5.6 -38.8 8.1 68 93 A V T 3 S+ 0 0 61 -20,-2.6 -19,-0.1 -2,-0.5 -1,-0.1 0.649 99.4 70.4 -63.6 -13.1 4.2 -36.6 5.4 69 94 A K T 3 S+ 0 0 136 -21,-0.3 2,-1.2 1,-0.2 -1,-0.3 0.582 79.3 81.3 -78.6 -12.6 0.8 -36.8 7.2 70 95 A E <> + 0 0 86 -3,-2.0 4,-2.1 1,-0.2 -1,-0.2 -0.677 56.4 168.7 -96.3 81.3 2.1 -34.7 10.0 71 96 A H H > S+ 0 0 127 -2,-1.2 4,-2.9 1,-0.2 5,-0.2 0.903 71.8 50.4 -63.4 -45.1 1.7 -31.3 8.5 72 97 A R H > S+ 0 0 219 1,-0.2 4,-2.2 2,-0.2 -1,-0.2 0.901 112.8 48.4 -61.1 -40.4 2.3 -29.1 11.6 73 98 A K H > S+ 0 0 124 2,-0.2 4,-2.2 1,-0.2 -1,-0.2 0.895 112.4 47.8 -66.1 -42.1 5.5 -31.0 12.3 74 99 A I H X S+ 0 0 17 -4,-2.1 4,-2.6 1,-0.2 -2,-0.2 0.932 111.7 50.6 -65.4 -43.6 6.7 -30.6 8.7 75 100 A Y H X S+ 0 0 99 -4,-2.9 4,-2.8 1,-0.2 -2,-0.2 0.892 109.5 52.0 -59.8 -40.0 5.8 -26.9 8.8 76 101 A T H X S+ 0 0 69 -4,-2.2 4,-1.3 2,-0.2 -1,-0.2 0.941 111.7 44.6 -61.0 -50.9 7.8 -26.5 12.0 77 102 A M H < S+ 0 0 13 -4,-2.2 4,-0.3 1,-0.2 -2,-0.2 0.882 114.4 49.3 -64.2 -40.2 10.9 -28.1 10.6 78 103 A I H >< S+ 0 0 0 -4,-2.6 3,-2.8 1,-0.2 -2,-0.2 0.955 106.3 55.8 -64.4 -47.9 10.7 -26.3 7.4 79 104 A Y H >< S+ 0 0 89 -4,-2.8 3,-1.2 1,-0.3 -1,-0.2 0.782 97.9 63.1 -54.1 -30.9 10.3 -22.9 9.1 80 105 A R T 3< S+ 0 0 177 -4,-1.3 -1,-0.3 1,-0.3 -2,-0.2 0.632 102.6 53.3 -68.4 -14.1 13.5 -23.5 11.0 81 106 A N T < S+ 0 0 20 -3,-2.8 -75,-2.6 -4,-0.3 2,-0.3 -0.041 109.4 42.9-113.8 33.1 15.2 -23.4 7.7 82 107 A L E < -B 5 0A 14 -3,-1.2 2,-0.5 -77,-0.3 -79,-0.0 -0.985 67.4-128.1-165.8 158.3 14.0 -20.1 6.3 83 108 A V E -B 4 0A 73 -79,-2.4 -79,-2.7 -2,-0.3 2,-0.5 -0.971 31.2-122.8-116.1 133.2 13.3 -16.5 7.2 84 109 A V E B 3 0A 78 -2,-0.5 -81,-0.2 -81,-0.2 -2,-0.0 -0.633 360.0 360.0 -77.1 123.9 9.9 -15.0 6.4 85 110 A V 0 0 113 -83,-2.5 -83,-0.3 -2,-0.5 -1,-0.1 -0.416 360.0 360.0 -67.9 360.0 10.2 -12.0 4.1