==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=5-JAN-2010 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER IMMUNE SYSTEM 23-JUN-08 2VWE . COMPND 2 MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR B; . SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; . AUTHOR P.LEONARD,P.D.SCOTNEY,T.JABEEN,S.IYER,L.J.FABRI,A.D.NASH, . 1060 6 16 14 2 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 48691.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 680 64.2 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 26 2.5 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 375 35.4 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 6 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 5 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 9 0.8 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 3 0.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 1 0.1 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 163 15.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 52 4.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 35 3.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 6 0.6 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 4 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 2 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 9 8 15 9 7 12 2 3 1 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 4 2 10 2 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 11 A Q 0 0 162 0, 0.0 2,-0.3 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 136.8 2.5 15.7 46.0 2 12 A R - 0 0 172 162,-0.0 2,-0.3 160,-0.0 162,-0.1 -0.966 360.0-142.2-154.4 165.1 3.7 12.3 44.9 3 13 A K - 0 0 180 -2,-0.3 162,-0.7 162,-0.0 2,-0.2 -0.966 16.8-122.7-137.2 154.0 2.6 8.7 44.2 4 14 A V E -a 165 0A 75 -2,-0.3 2,-0.5 160,-0.1 162,-0.2 -0.557 18.6-130.2 -94.7 156.1 3.9 5.2 44.8 5 15 A V E -a 166 0A 47 160,-1.5 162,-1.7 -2,-0.2 2,-0.1 -0.922 24.0-119.1-109.3 130.6 4.6 2.4 42.2 6 16 A S > - 0 0 20 -2,-0.5 4,-1.4 160,-0.1 3,-0.3 -0.391 18.7-125.5 -65.6 140.5 3.3 -1.1 42.7 7 17 A W H > S+ 0 0 2 1,-0.2 4,-2.5 2,-0.2 5,-0.2 0.817 111.2 58.4 -58.1 -35.3 5.9 -3.9 42.9 8 18 A I H > S+ 0 0 3 1,-0.2 4,-2.1 2,-0.2 -1,-0.2 0.942 108.6 44.8 -57.3 -48.9 4.2 -5.8 40.1 9 19 A D H > S+ 0 0 73 -3,-0.3 4,-0.9 1,-0.2 -2,-0.2 0.740 110.8 57.6 -66.5 -25.3 4.7 -2.7 37.8 10 20 A V H X S+ 0 0 3 -4,-1.4 4,-0.6 2,-0.1 131,-0.3 0.951 114.4 33.2 -69.9 -51.8 8.2 -2.5 39.1 11 21 A Y H X S+ 0 0 2 -4,-2.5 4,-2.2 2,-0.2 -2,-0.2 0.771 107.3 69.0 -78.8 -27.2 9.4 -6.0 38.0 12 22 A T H < S+ 0 0 50 -4,-2.1 -1,-0.2 -5,-0.2 -2,-0.1 0.913 111.5 32.1 -58.8 -46.2 7.2 -6.3 34.9 13 23 A R H < S+ 0 0 85 -4,-0.9 -1,-0.2 1,-0.2 -2,-0.2 0.610 119.1 56.9 -84.5 -14.2 9.2 -3.6 33.1 14 24 A A H < S+ 0 0 0 -4,-0.6 36,-2.4 35,-0.1 -2,-0.2 0.709 85.6 97.8 -88.2 -24.0 12.4 -4.7 34.9 15 25 A T S < S- 0 0 2 -4,-2.2 36,-0.2 34,-0.2 2,-0.2 -0.299 94.8 -79.6 -66.5 148.7 12.3 -8.3 33.8 16 26 A a S S+ 0 0 0 34,-0.4 33,-0.2 33,-0.1 -1,-0.2 -0.291 77.9 126.5 -48.2 111.3 14.4 -9.5 30.8 17 27 A Q E -D 48 0B 42 31,-1.6 31,-1.5 -2,-0.2 2,-0.3 -0.968 66.0 -76.0-153.7 173.5 12.6 -8.5 27.7 18 28 A P E +D 47 0B 32 0, 0.0 2,-0.3 0, 0.0 29,-0.2 -0.588 58.4 170.7 -69.8 128.9 13.1 -6.6 24.4 19 29 A R E -D 46 0B 5 27,-2.8 27,-3.2 -2,-0.3 2,-0.5 -0.954 40.8 -89.3-142.8 158.4 13.1 -2.8 25.0 20 30 A E E +D 45 0B 67 -2,-0.3 2,-0.4 25,-0.2 25,-0.2 -0.563 49.0 176.7 -72.9 116.6 13.8 0.5 23.2 21 31 A V E -D 44 0B 51 23,-2.2 23,-2.1 -2,-0.5 2,-0.3 -0.983 27.8-125.1-127.1 133.2 17.4 1.5 23.7 22 32 A V E -D 43 0B 45 -2,-0.4 21,-0.2 21,-0.2 90,-0.0 -0.564 23.2-163.5 -74.7 135.5 19.3 4.5 22.3 23 33 A V E -D 42 0B 17 19,-3.1 19,-2.1 -2,-0.3 2,-0.3 -0.976 15.3-133.5-125.3 117.6 22.5 3.7 20.3 24 34 A P E -D 41 0B 90 0, 0.0 2,-0.7 0, 0.0 17,-0.3 -0.533 23.9-122.8 -70.0 128.2 25.1 6.4 19.6 25 35 A L + 0 0 25 15,-2.4 2,-0.3 -2,-0.3 12,-0.2 -0.631 40.9 175.9 -76.4 111.6 26.3 6.3 15.9 26 36 A T >> - 0 0 63 -2,-0.7 4,-3.1 1,-0.1 3,-0.8 -0.844 44.0-125.6-119.1 154.6 30.1 5.9 15.9 27 37 A V T 34 S+ 0 0 107 -2,-0.3 5,-0.1 1,-0.2 -1,-0.1 0.708 113.3 60.5 -67.0 -21.0 32.7 5.4 13.2 28 38 A E T 34 S+ 0 0 184 1,-0.1 -1,-0.2 3,-0.1 3,-0.2 0.738 114.4 33.3 -76.2 -26.3 33.8 2.3 15.1 29 39 A L T <4 S+ 0 0 103 -3,-0.8 2,-0.4 1,-0.4 -2,-0.2 0.841 135.6 18.7 -96.8 -47.4 30.3 0.8 14.6 30 40 A M S < S- 0 0 29 -4,-3.1 -1,-0.4 1,-0.1 3,-0.2 -0.994 84.5-140.4-127.5 128.0 29.4 2.3 11.2 31 41 A G - 0 0 47 -2,-0.4 2,-0.6 1,-0.2 3,-0.3 0.428 47.0 -29.4 -72.8-155.4 32.1 3.6 8.9 32 42 A T S S+ 0 0 132 1,-0.2 -1,-0.2 -5,-0.1 3,-0.1 -0.474 72.2 121.7 -73.3 108.9 32.6 6.6 6.6 33 43 A V S S- 0 0 58 -2,-0.6 2,-0.3 1,-0.6 -1,-0.2 0.402 86.6 -11.6-127.5 -23.6 29.3 7.8 5.0 34 44 A A - 0 0 25 -3,-0.3 -1,-0.6 1,-0.1 3,-0.2 -0.962 60.5-112.9-166.0 163.9 29.6 11.4 6.4 35 45 A K S S+ 0 0 207 38,-1.1 2,-0.4 1,-0.3 39,-0.1 0.817 111.3 18.9 -72.5 -33.7 31.5 13.5 8.9 36 46 A Q S S- 0 0 56 37,-0.5 37,-1.5 -3,-0.1 2,-0.4 -0.995 74.2-149.9-139.3 132.2 28.2 13.8 10.9 37 47 A L E -E 72 0C 25 -2,-0.4 35,-0.2 -12,-0.2 -12,-0.1 -0.829 28.1-112.1-100.2 140.5 25.1 11.5 10.7 38 48 A V E S+E 71 0C 3 33,-2.3 33,-2.0 -2,-0.4 2,-0.1 -0.970 107.2 26.3-122.1 119.4 21.7 13.0 11.4 39 49 A P S S- 0 0 1 0, 0.0 -1,-0.2 0, 0.0 110,-0.1 0.601 84.9-150.7 -72.0 157.4 20.4 12.0 13.9 40 50 A S S S+ 0 0 46 109,-0.4 -15,-2.4 -2,-0.1 2,-0.3 0.431 81.8 32.7 -75.8 0.2 23.7 11.2 15.6 41 51 A b E -D 24 0B 7 -17,-0.3 2,-0.2 107,-0.1 107,-0.2 -0.983 69.3-164.9-151.7 152.1 21.9 8.4 17.5 42 52 A V E -D 23 0B 1 -19,-2.1 -19,-3.1 -2,-0.3 2,-0.4 -0.810 20.1-113.5-132.4 174.7 19.0 6.0 16.8 43 53 A T E +D 22 0B 20 -2,-0.2 2,-0.3 -21,-0.2 -21,-0.2 -0.950 32.0 168.5-117.6 129.6 16.7 3.6 18.7 44 54 A V E -D 21 0B 3 -23,-2.1 -23,-2.2 -2,-0.4 2,-0.7 -0.971 42.3-101.4-135.4 152.3 16.6 -0.2 18.4 45 55 A Q E +D 20 0B 85 -2,-0.3 43,-1.9 -25,-0.2 2,-0.3 -0.629 52.0 173.0 -75.8 109.8 14.8 -3.0 20.3 46 56 A R E -D 19 0B 74 -27,-3.2 -27,-2.8 -2,-0.7 2,-1.1 -0.852 40.8-101.7-122.0 155.3 17.5 -4.5 22.6 47 57 A c E +D 18 0B 25 -2,-0.3 2,-0.2 -29,-0.2 -31,-0.1 -0.631 57.7 155.7 -78.8 97.3 17.5 -7.1 25.4 48 58 A G E +D 17 0B 11 -31,-1.5 -31,-1.6 -2,-1.1 2,-0.2 -0.739 22.6 54.9-117.6 168.7 17.7 -5.1 28.6 49 59 A G S S- 0 0 24 -2,-0.2 2,-0.3 -33,-0.2 -34,-0.2 -0.685 72.4 -79.5 109.9-163.9 16.7 -5.6 32.2 50 60 A d - 0 0 17 -36,-2.4 -34,-0.4 -2,-0.2 89,-0.1 -0.999 27.1-121.9-147.6 145.2 17.6 -8.3 34.8 51 61 A e - 0 0 5 5,-0.6 87,-0.4 -2,-0.3 5,-0.1 -0.448 28.4-116.9 -82.4 156.9 16.5 -11.8 35.7 52 62 A P S S+ 0 0 21 0, 0.0 2,-0.2 0, 0.0 -1,-0.1 0.912 97.3 62.6 -60.7 -46.8 15.0 -12.8 39.2 53 63 A D S > S- 0 0 65 1,-0.1 3,-1.1 459,-0.1 -2,-0.2 -0.555 80.8-134.2 -83.5 147.0 17.9 -15.2 40.1 54 64 A D T 3 S+ 0 0 103 1,-0.3 -1,-0.1 -2,-0.2 -3,-0.1 0.833 104.3 56.1 -68.5 -35.4 21.5 -13.9 40.5 55 65 A G T 3 S+ 0 0 31 2,-0.0 41,-1.4 41,-0.0 2,-0.5 0.167 91.4 92.6 -84.2 18.2 23.0 -16.8 38.4 56 66 A L E < - F 0 95C 15 -3,-1.1 -5,-0.6 39,-0.2 2,-0.2 -0.962 60.7-159.3-119.8 120.0 20.7 -15.9 35.5 57 67 A E E - F 0 94C 68 37,-2.0 37,-1.4 -2,-0.5 2,-0.8 -0.662 20.6-119.4 -98.9 152.0 21.9 -13.6 32.7 58 68 A a E + F 0 93C 35 -2,-0.2 35,-0.2 -9,-0.2 -9,-0.1 -0.803 46.6 157.9 -93.7 106.2 19.8 -11.6 30.2 59 69 A V E - F 0 92C 31 33,-1.9 33,-2.5 -2,-0.8 2,-0.1 -0.967 41.9-104.2-131.4 144.7 20.7 -12.7 26.6 60 70 A P E - F 0 91C 44 0, 0.0 31,-0.3 0, 0.0 3,-0.1 -0.387 16.2-159.1 -67.1 142.0 18.9 -12.6 23.2 61 71 A T E S- 0 0 70 29,-3.4 2,-0.3 1,-0.4 30,-0.2 0.912 76.4 -6.7 -81.1 -52.7 17.3 -15.8 21.8 62 72 A G E - F 0 90C 25 28,-0.9 27,-2.8 2,-0.0 28,-1.0 -0.989 65.0-157.0-146.3 151.6 17.2 -14.5 18.2 63 73 A Q E - F 0 88C 98 -2,-0.3 2,-0.4 25,-0.3 25,-0.3 -0.968 4.3-160.3-134.6 147.0 17.9 -11.3 16.3 64 74 A H E - F 0 87C 90 23,-3.0 23,-0.9 -2,-0.3 2,-0.5 -0.995 23.3-127.3-127.8 129.9 16.9 -9.7 13.0 65 75 A Q E - F 0 86C 130 -2,-0.4 2,-0.3 21,-0.2 21,-0.2 -0.645 26.6-163.7 -82.0 120.5 18.8 -6.9 11.4 66 76 A V E - F 0 85C 22 19,-2.0 19,-2.9 -2,-0.5 2,-0.4 -0.755 9.6-137.5-103.5 150.0 16.7 -3.8 10.5 67 77 A R E -gF 102 84C 77 34,-0.9 36,-2.0 -2,-0.3 2,-0.3 -0.894 17.3-163.9-110.8 137.5 17.6 -1.0 8.1 68 78 A M E -gF 103 83C 5 15,-3.0 15,-2.6 -2,-0.4 2,-0.5 -0.918 23.9-116.2-123.9 144.8 17.0 2.7 8.8 69 79 A Q E - F 0 82C 23 34,-2.0 2,-0.4 -2,-0.3 13,-0.3 -0.668 40.9-178.0 -78.6 124.3 16.9 5.9 6.7 70 80 A I E - F 0 81C 2 11,-1.8 11,-1.9 -2,-0.5 2,-0.6 -0.987 29.9-121.7-133.4 134.8 19.7 8.2 7.8 71 81 A L E -EF 38 80C 0 -33,-2.0 -33,-2.3 -2,-0.4 2,-0.7 -0.647 26.2-157.5 -75.6 113.7 20.7 11.7 6.6 72 82 A M E -EF 37 79C 22 7,-3.0 7,-2.0 -2,-0.6 2,-1.5 -0.850 8.8-144.7 -96.5 108.9 24.3 11.6 5.5 73 83 A I + 0 0 10 -37,-1.5 -38,-1.1 -2,-0.7 -37,-0.5 -0.598 31.2 169.3 -75.0 91.5 26.0 15.0 5.6 74 84 A R - 0 0 134 -2,-1.5 4,-0.1 -40,-0.2 -40,-0.1 -0.920 30.6-150.7-109.1 134.7 28.3 14.8 2.6 75 85 A Y S S+ 0 0 202 -2,-0.4 3,-0.1 1,-0.2 -1,-0.1 0.643 97.2 56.2 -87.4 -16.2 29.9 18.1 1.5 76 86 A P S S- 0 0 114 0, 0.0 -1,-0.2 0, 0.0 2,-0.2 0.923 140.5 -23.1 -71.0 -52.2 30.1 17.0 -2.2 77 87 A S S S- 0 0 43 2,-0.0 -2,-0.2 584,-0.0 2,-0.1 -0.695 70.3-130.0-159.6 116.3 26.3 16.5 -2.0 78 88 A S - 0 0 16 -2,-0.2 2,-0.3 -3,-0.1 -5,-0.2 -0.388 35.0-177.3 -64.9 131.2 24.3 15.9 1.2 79 89 A Q E -F 72 0C 79 -7,-2.0 -7,-3.0 -2,-0.1 2,-1.0 -0.970 34.9-125.6-135.8 148.1 22.0 12.9 0.8 80 90 A L E +F 71 0C 14 -2,-0.3 -9,-0.3 -9,-0.3 25,-0.0 -0.799 51.9 165.0 -89.8 98.0 19.4 11.0 2.8 81 91 A G E -F 70 0C 16 -11,-1.9 -11,-1.8 -2,-1.0 2,-0.4 0.075 31.6 -95.4-100.5-153.7 20.8 7.4 2.6 82 92 A E E +F 69 0C 103 -13,-0.3 2,-0.3 -11,-0.0 -13,-0.2 -0.992 29.9 173.6-137.5 138.1 20.4 4.1 4.3 83 93 A M E -F 68 0C 25 -15,-2.6 -15,-3.0 -2,-0.4 2,-0.3 -0.916 17.7-137.9-136.1 166.0 22.1 2.2 7.2 84 94 A S E -F 67 0C 71 -2,-0.3 2,-0.3 -17,-0.3 -17,-0.2 -0.938 14.6-177.5-129.8 149.1 21.5 -1.1 9.1 85 95 A L E -F 66 0C 13 -19,-2.9 -19,-2.0 -2,-0.3 2,-0.3 -0.991 32.4-105.6-143.0 151.1 21.7 -2.3 12.7 86 96 A E E -F 65 0C 78 -2,-0.3 2,-0.4 -21,-0.2 -21,-0.2 -0.598 37.8-173.4 -77.7 131.7 21.2 -5.5 14.6 87 97 A E E -F 64 0C 29 -23,-0.9 -23,-3.0 -2,-0.3 -41,-0.2 -0.993 18.4-126.9-132.9 132.5 17.9 -5.7 16.6 88 98 A H E -F 63 0C 27 -43,-1.9 -25,-0.3 -2,-0.4 3,-0.1 -0.408 13.0-167.9 -78.6 152.1 16.8 -8.4 19.0 89 99 A S E - 0 0 68 -27,-2.8 2,-0.3 1,-0.4 -26,-0.2 0.816 69.7 -6.2-102.8 -50.2 13.4 -10.3 18.7 90 100 A Q E -F 62 0C 82 -28,-1.0 -29,-3.4 -73,-0.1 -28,-0.9 -0.985 61.1-148.4-148.4 155.1 13.1 -12.1 22.1 91 101 A c E -F 60 0C 0 -2,-0.3 2,-0.3 -31,-0.3 350,-0.2 -0.844 9.2-168.9-124.6 159.2 15.2 -12.7 25.2 92 102 A E E -F 59 0C 39 -33,-2.5 -33,-1.9 -2,-0.3 2,-0.6 -0.957 25.1-115.2-142.9 162.3 15.6 -15.5 27.8 93 103 A e E -F 58 0C 0 -2,-0.3 -35,-0.2 -35,-0.2 -37,-0.0 -0.899 37.0-180.0-102.7 119.8 17.3 -16.1 31.2 94 104 A R E -F 57 0C 112 -37,-1.4 -37,-2.0 -2,-0.6 372,-0.1 -0.844 33.1-101.2-116.4 152.0 20.1 -18.7 31.2 95 105 A P E -F 56 0C 80 0, 0.0 -39,-0.2 0, 0.0 2,-0.2 -0.441 44.6-122.8 -64.3 146.7 22.3 -20.2 33.9 96 106 A K 0 0 117 -41,-1.4 -41,-0.0 1,-0.1 -40,-0.0 -0.490 360.0 360.0 -94.6 162.0 25.9 -18.8 33.8 97 107 A K 0 0 156 -2,-0.2 -1,-0.1 0, 0.0 -42,-0.0 0.678 360.0 360.0-115.8 360.0 29.3 -20.4 33.4 98 !* 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 99 11 B Q 0 0 152 0, 0.0 2,-0.3 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 -32.1 11.0 -10.3 5.3 100 12 B R - 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