==== Secondary Structure Definition by the program DSSP, updated CMBI version by ElmK / April 1,2000 ==== DATE=18-MAR-2012 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 28-JUL-10 2XMI . COMPND 2 MOLECULE: 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE; . SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; . AUTHOR M.MYLLYKOSKI,P.KURSULA . 216 2 0 0 0 TOTAL NUMBER OF RESIDUES, NUMBER OF CHAINS, NUMBER OF SS-BRIDGES(TOTAL,INTRACHAIN,INTERCHAIN) . 12426.0 ACCESSIBLE SURFACE OF PROTEIN (ANGSTROM**2) . 154 71.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(J) , SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS IN PARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 55 25.5 TOTAL NUMBER OF HYDROGEN BONDS IN ANTIPARALLEL BRIDGES, SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-5), SAME NUMBER PER 100 RESIDUES . 1 0.5 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-4), SAME NUMBER PER 100 RESIDUES . 3 1.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-3), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-2), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I-1), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+0), SAME NUMBER PER 100 RESIDUES . 0 0.0 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+1), SAME NUMBER PER 100 RESIDUES . 16 7.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+2), SAME NUMBER PER 100 RESIDUES . 29 13.4 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+3), SAME NUMBER PER 100 RESIDUES . 46 21.3 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+4), SAME NUMBER PER 100 RESIDUES . 2 0.9 TOTAL NUMBER OF HYDROGEN BONDS OF TYPE O(I)-->H-N(I+5), SAME NUMBER PER 100 RESIDUES . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 *** HISTOGRAMS OF *** . 0 0 0 3 2 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 RESIDUES PER ALPHA HELIX . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PARALLEL BRIDGES PER LADDER . 1 0 1 0 2 3 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANTIPARALLEL BRIDGES PER LADDER . 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 LADDERS PER SHEET . # RESIDUE AA STRUCTURE BP1 BP2 ACC N-H-->O O-->H-N N-H-->O O-->H-N TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA 1 160 A L 0 0 235 0, 0.0 2,-0.4 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 146.5 -24.5 -16.5 46.6 2 161 A E - 0 0 182 1,-0.1 3,-0.0 3,-0.0 0, 0.0 -0.848 360.0-117.8-103.8 138.3 -22.1 -14.5 44.5 3 162 A K - 0 0 163 -2,-0.4 2,-0.4 1,-0.1 -1,-0.1 -0.224 29.5-108.1 -64.1 157.9 -21.9 -14.9 40.7 4 163 A D - 0 0 150 1,-0.0 2,-0.1 0, 0.0 -1,-0.1 -0.756 35.8-129.3 -82.7 134.1 -18.7 -16.1 39.1 5 164 A F - 0 0 141 -2,-0.4 73,-0.2 1,-0.1 72,-0.1 -0.465 19.4-123.1 -83.0 162.0 -17.0 -13.3 37.2 6 165 A L - 0 0 33 71,-1.7 -1,-0.1 1,-0.2 73,-0.1 -0.363 35.4 -80.3 -94.2 175.3 -15.9 -13.7 33.6 7 166 A P - 0 0 3 0, 0.0 70,-2.0 0, 0.0 71,-0.3 -0.188 35.5-114.1 -63.4 167.2 -12.4 -13.2 32.1 8 167 A L S S- 0 0 34 207,-2.5 68,-2.4 1,-0.3 67,-2.4 0.909 98.3 -18.8 -63.2 -46.1 -10.9 -9.8 31.3 9 168 A Y E -AB 74 215A 28 206,-1.5 206,-2.9 65,-0.3 -1,-0.3 -0.985 61.7-130.7-155.6 156.8 -11.2 -11.1 27.8 10 169 A F E +AB 73 214A 11 63,-2.3 62,-2.5 -2,-0.3 63,-0.6 -0.786 46.4 122.0 -97.2 152.3 -11.5 -14.3 25.7 11 170 A G E -AB 71 213A 0 202,-2.3 202,-2.7 -2,-0.3 2,-0.6 -0.983 60.9 -68.8 176.7-177.8 -9.2 -15.0 22.8 12 171 A W E -AB 70 212A 0 58,-2.7 58,-2.6 -2,-0.3 2,-0.6 -0.852 39.3-157.3 -94.8 123.3 -6.6 -17.2 21.1 13 172 A F E -AB 69 211A 31 198,-2.8 198,-2.6 -2,-0.6 56,-0.2 -0.904 18.2-130.0-104.9 117.6 -3.2 -17.3 22.9 14 173 A L E - B 0 210A 4 54,-2.2 196,-0.3 -2,-0.6 53,-0.0 -0.272 24.0-108.1 -65.9 148.3 -0.4 -18.3 20.6 15 174 A T > - 0 0 39 194,-2.3 4,-2.8 1,-0.1 53,-0.3 -0.209 35.0-101.6 -66.1 168.5 2.0 -21.0 21.7 16 175 A K H > S+ 0 0 153 2,-0.2 4,-2.3 1,-0.2 5,-0.2 0.942 123.5 46.7 -56.0 -49.7 5.5 -20.0 22.7 17 176 A K H > S+ 0 0 153 1,-0.2 4,-2.1 2,-0.2 -1,-0.2 0.932 114.5 45.2 -61.7 -48.9 6.9 -21.1 19.3 18 177 A S H > S+ 0 0 13 1,-0.2 4,-2.6 2,-0.2 5,-0.3 0.882 112.1 52.2 -63.8 -38.8 4.2 -19.4 17.2 19 178 A S H X S+ 0 0 5 -4,-2.8 4,-2.8 1,-0.2 -1,-0.2 0.911 110.0 49.2 -64.7 -40.2 4.5 -16.2 19.3 20 179 A E H X S+ 0 0 79 -4,-2.3 4,-2.3 -5,-0.2 -2,-0.2 0.910 112.0 48.5 -63.7 -41.7 8.2 -16.1 18.7 21 180 A T H X S+ 0 0 66 -4,-2.1 4,-1.7 2,-0.2 -2,-0.2 0.917 116.4 41.3 -65.3 -46.3 7.8 -16.6 15.0 22 181 A L H X S+ 0 0 0 -4,-2.6 4,-2.5 2,-0.2 -2,-0.2 0.914 113.8 53.5 -68.4 -42.3 5.2 -13.9 14.6 23 182 A R H X S+ 0 0 90 -4,-2.8 4,-2.3 -5,-0.3 -2,-0.2 0.928 110.6 46.7 -57.6 -45.9 7.0 -11.5 16.9 24 183 A K H X S+ 0 0 130 -4,-2.3 4,-2.4 1,-0.2 -1,-0.2 0.875 110.7 52.4 -65.7 -36.8 10.3 -11.9 14.9 25 184 A A H X S+ 0 0 6 -4,-1.7 4,-2.2 1,-0.2 -1,-0.2 0.911 109.8 49.8 -65.9 -41.4 8.4 -11.4 11.7 26 185 A G H X S+ 0 0 7 -4,-2.5 4,-2.2 2,-0.2 -2,-0.2 0.914 111.0 48.7 -60.4 -44.6 6.9 -8.2 13.1 27 186 A Q H X S+ 0 0 67 -4,-2.3 4,-1.9 2,-0.2 -2,-0.2 0.890 110.0 50.9 -65.8 -40.7 10.3 -6.9 14.2 28 187 A V H X S+ 0 0 63 -4,-2.4 4,-2.7 1,-0.2 -1,-0.2 0.913 108.8 52.6 -63.3 -41.8 11.8 -7.6 10.8 29 188 A F H X S+ 0 0 6 -4,-2.2 4,-3.2 1,-0.2 5,-0.3 0.927 107.2 51.9 -58.2 -46.5 9.0 -5.7 9.1 30 189 A L H X S+ 0 0 19 -4,-2.2 4,-2.0 1,-0.2 26,-0.4 0.888 111.8 47.1 -58.0 -40.2 9.5 -2.7 11.4 31 190 A E H X S+ 0 0 91 -4,-1.9 4,-1.2 2,-0.2 -2,-0.2 0.935 115.3 44.6 -66.5 -46.0 13.2 -2.7 10.4 32 191 A E H X S+ 0 0 54 -4,-2.7 4,-0.8 2,-0.2 -2,-0.2 0.906 114.0 49.3 -66.3 -43.4 12.5 -3.1 6.7 33 192 A L H >< S+ 0 0 0 -4,-3.2 3,-0.9 1,-0.2 6,-0.3 0.938 111.2 48.7 -60.5 -48.0 9.7 -0.5 6.7 34 193 A G H 3< S+ 0 0 2 -4,-2.0 20,-0.2 -5,-0.3 -1,-0.2 0.724 112.2 49.3 -68.5 -22.0 11.8 2.1 8.5 35 194 A N H 3< S+ 0 0 89 -4,-1.2 -1,-0.3 -3,-0.2 2,-0.2 0.616 89.6 108.4 -84.5 -15.7 14.7 1.6 6.2 36 195 A H XX - 0 0 47 -3,-0.9 4,-2.5 -4,-0.8 3,-0.7 -0.429 68.5-139.2 -76.2 131.2 12.5 1.9 3.1 37 196 A K H 3> S+ 0 0 165 1,-0.3 4,-2.1 -2,-0.2 5,-0.2 0.880 103.5 56.2 -51.4 -43.5 12.8 5.1 1.0 38 197 A A H 3> S+ 0 0 16 1,-0.2 4,-0.5 2,-0.2 -1,-0.3 0.853 111.0 43.9 -61.3 -36.2 9.1 5.3 0.5 39 198 A F H X4 S+ 0 0 3 -3,-0.7 3,-1.3 -6,-0.3 -2,-0.2 0.937 110.6 53.1 -72.9 -48.1 8.5 5.3 4.3 40 199 A K H >< S+ 0 0 92 -4,-2.5 3,-1.3 1,-0.3 4,-0.2 0.856 104.2 57.6 -56.7 -37.2 11.3 7.8 5.0 41 200 A K H 3< S+ 0 0 150 -4,-2.1 3,-0.3 1,-0.2 -1,-0.3 0.762 108.9 45.5 -65.5 -24.5 9.9 10.3 2.5 42 201 A E T XX S+ 0 0 71 -3,-1.3 3,-1.7 -4,-0.5 4,-0.5 0.233 72.4 117.8-104.0 13.0 6.5 10.3 4.3 43 202 A L H X> + 0 0 33 -3,-1.3 4,-3.0 1,-0.3 3,-1.4 0.816 69.9 64.0 -53.7 -32.7 7.9 10.7 7.9 44 203 A R H 34 S+ 0 0 222 -3,-0.3 -1,-0.3 1,-0.3 -2,-0.1 0.875 102.8 47.9 -56.4 -39.5 6.1 14.1 8.1 45 204 A H H <4 S+ 0 0 123 -3,-1.7 -1,-0.3 1,-0.1 -2,-0.2 0.477 115.0 49.0 -80.3 -1.9 2.8 12.2 7.8 46 205 A F H << S+ 0 0 10 -3,-1.4 2,-0.3 -4,-0.5 -2,-0.2 0.854 125.5 3.2-100.7 -55.7 4.0 9.8 10.4 47 206 A I < - 0 0 51 -4,-3.0 -1,-0.4 2,-0.1 149,-0.0 -0.876 52.4-144.0-124.5 164.5 5.3 12.1 13.2 48 207 A S S S+ 0 0 134 -2,-0.3 2,-0.5 -3,-0.1 -4,-0.1 0.449 76.5 95.5-100.2 -4.2 5.3 15.9 13.6 49 208 A G 0 0 48 1,-0.0 -2,-0.1 -5,-0.0 0, 0.0 -0.789 360.0 360.0 -98.6 124.4 8.7 15.8 15.3 50 209 A D 0 0 211 -2,-0.5 -2,-0.0 -6,-0.0 -6,-0.0 -0.785 360.0 360.0 -94.7 360.0 11.9 16.4 13.4 51 ! 0 0 0 0, 0.0 0, 0.0 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 360.0 0.0 0.0 0.0 52 213 A E 0 0 246 0, 0.0 2,-0.3 0, 0.0 0, 0.0 0.000 360.0 360.0 360.0 174.1 17.9 11.6 10.8 53 214 A K - 0 0 72 2,-0.0 2,-0.6 -18,-0.0 -18,-0.1 -0.808 360.0-133.9-109.7 140.9 16.1 8.2 10.8 54 215 A L - 0 0 37 -2,-0.3 2,-0.9 -20,-0.2 3,-0.1 -0.827 14.4-147.4 -91.8 122.7 13.2 6.9 12.9 55 216 A E >> - 0 0 95 -2,-0.6 4,-1.8 1,-0.2 3,-0.9 -0.808 6.9-161.3 -88.5 108.0 13.7 3.4 14.3 56 217 A L H 3> S+ 0 0 1 -2,-0.9 4,-2.6 -26,-0.4 -1,-0.2 0.763 86.2 64.2 -64.0 -28.3 10.2 1.9 14.4 57 218 A V H 34 S+ 0 0 41 1,-0.2 -1,-0.3 2,-0.2 -26,-0.0 0.897 110.7 40.0 -63.1 -34.8 11.2 -0.8 16.9 58 219 A S H X4 S+ 0 0 88 -3,-0.9 3,-0.6 1,-0.2 -2,-0.2 0.816 110.3 58.2 -77.3 -35.7 11.8 2.0 19.4 59 220 A Y H 3< S+ 0 0 51 -4,-1.8 2,-1.4 1,-0.3 96,-0.4 0.923 105.1 51.5 -62.0 -43.8 8.8 4.0 18.2 60 221 A F T 3< S+ 0 0 3 -4,-2.6 -1,-0.3 1,-0.2 94,-0.2 -0.421 74.8 152.9 -89.2 62.6 6.5 1.1 19.1 61 222 A G < + 0 0 37 -2,-1.4 2,-0.8 -3,-0.6 -1,-0.2 0.669 49.5 74.3 -72.5 -21.1 8.1 0.9 22.6 62 223 A K B +C 153 0A 81 91,-1.8 91,-2.2 -3,-0.2 -1,-0.1 -0.864 67.1 158.4 -94.5 111.7 5.1 -0.7 24.3 63 224 A R - 0 0 133 -2,-0.8 89,-0.2 89,-0.2 88,-0.1 -0.911 50.4 -81.7-129.9 158.6 5.0 -4.3 23.2 64 225 A P - 0 0 38 0, 0.0 4,-0.1 0, 0.0 -2,-0.0 -0.407 36.0-145.5 -58.2 131.9 3.5 -7.6 24.6 65 226 A P S S- 0 0 143 0, 0.0 3,-0.1 0, 0.0 2,-0.0 0.854 74.4 -7.1 -68.5 -39.1 5.9 -9.0 27.3 66 227 A G S S+ 0 0 47 1,-0.4 2,-0.0 -3,-0.0 0, 0.0 0.144 115.3 11.2-127.5-122.0 5.3 -12.7 26.5 67 228 A V - 0 0 73 1,-0.1 -1,-0.4 -54,-0.0 2,-0.2 -0.338 68.6-124.4 -69.1 150.8 3.0 -14.7 24.3 68 229 A L - 0 0 4 -53,-0.3 -54,-2.2 -3,-0.1 2,-0.3 -0.504 28.6-166.2 -87.5 159.3 0.9 -12.9 21.7 69 230 A H E -A 13 0A 48 81,-0.2 81,-0.6 -56,-0.2 2,-0.5 -0.975 24.1-141.4-146.4 161.0 -2.9 -13.2 21.4 70 231 A C E -A 12 0A 0 -58,-2.6 -58,-2.7 -2,-0.3 79,-0.2 -0.963 30.1-142.6-120.6 109.1 -5.9 -12.6 19.2 71 232 A T E +A 11 0A 33 -2,-0.5 -60,-0.3 77,-0.4 77,-0.3 -0.440 22.5 178.2 -73.3 141.7 -8.8 -11.3 21.3 72 233 A T E S+ 0 0 8 -62,-2.5 2,-0.5 1,-0.2 -61,-0.2 0.756 73.1 7.3 -99.6 -63.6 -12.4 -12.4 20.4 73 234 A K E -A 10 0A 19 -63,-0.6 -63,-2.3 55,-0.1 2,-0.5 -0.960 62.0-145.6-129.8 118.8 -14.5 -10.7 23.1 74 235 A F E +A 9 0A 104 -2,-0.5 -65,-0.3 -65,-0.2 -66,-0.1 -0.708 25.4 171.4 -76.7 123.7 -13.3 -8.1 25.7 75 236 A C > > - 0 0 0 -67,-2.4 5,-2.4 -2,-0.5 3,-2.0 0.687 28.6-147.6-109.5 -25.2 -15.4 -8.9 28.8 76 237 A D G > 5S- 0 0 51 -68,-2.4 3,-1.9 1,-0.3 -68,-0.3 0.900 76.8 -59.6 47.2 45.7 -14.0 -6.7 31.7 77 238 A Y G 3 5S- 0 0 71 -70,-2.0 -71,-1.7 1,-0.3 -1,-0.3 0.520 109.1 -42.9 66.7 9.1 -15.0 -9.5 34.0 78 239 A G G < 5S+ 0 0 16 -3,-2.0 6,-0.3 -71,-0.3 -1,-0.3 0.192 120.4 102.6 120.1 -14.1 -18.6 -9.2 33.0 79 240 A K T < 5 + 0 0 163 -3,-1.9 -3,-0.2 -4,-0.2 2,-0.1 0.738 59.0 90.4 -73.5 -25.6 -18.8 -5.4 33.0 80 241 A A S > S+ 0 0 18 -4,-0.1 4,-2.3 -2,-0.1 -1,-0.3 0.452 90.9 119.3 82.8 0.9 -22.6 -8.4 25.8 83 244 A A H <> S+ 0 0 0 -3,-1.9 4,-2.4 2,-0.2 5,-0.2 0.945 75.5 44.3 -65.5 -48.6 -20.0 -10.1 27.9 84 245 A E H > S+ 0 0 95 -4,-0.4 4,-1.5 -6,-0.3 -1,-0.2 0.902 113.8 51.6 -63.5 -40.5 -22.4 -12.5 29.7 85 246 A E H 4 S+ 0 0 107 1,-0.2 4,-0.5 2,-0.2 -1,-0.2 0.899 111.2 47.5 -64.7 -42.2 -24.2 -13.3 26.5 86 247 A Y H >< S+ 0 0 6 -4,-2.3 3,-1.2 1,-0.2 6,-0.2 0.939 112.1 49.0 -61.0 -48.3 -20.9 -14.1 24.7 87 248 A A H 3< S+ 0 0 12 -4,-2.4 -1,-0.2 1,-0.3 -2,-0.2 0.756 103.9 59.4 -68.1 -26.0 -19.6 -16.3 27.6 88 249 A Q T 3< S+ 0 0 123 -4,-1.5 -1,-0.3 -5,-0.2 -2,-0.2 0.610 78.3 116.6 -80.8 -11.4 -22.8 -18.4 27.9 89 250 A Q <> - 0 0 72 -3,-1.2 4,-2.2 -4,-0.5 3,-0.3 -0.311 68.1-134.2 -62.1 137.5 -22.7 -19.6 24.3 90 251 A E H > S+ 0 0 161 1,-0.2 4,-3.1 2,-0.2 5,-0.3 0.907 105.6 55.6 -55.8 -44.8 -22.3 -23.4 23.9 91 252 A V H > S+ 0 0 19 1,-0.2 4,-1.8 2,-0.2 -1,-0.2 0.873 107.8 49.3 -61.5 -34.3 -19.6 -22.9 21.3 92 253 A V H > S+ 0 0 2 -3,-0.3 4,-0.8 -6,-0.2 -1,-0.2 0.947 114.4 43.6 -68.3 -46.1 -17.5 -20.8 23.7 93 254 A K H >< S+ 0 0 142 -4,-2.2 3,-0.6 1,-0.2 -2,-0.2 0.919 115.6 48.9 -64.3 -41.9 -17.8 -23.3 26.5 94 255 A R H 3< S+ 0 0 157 -4,-3.1 -1,-0.2 1,-0.2 -2,-0.2 0.832 113.6 46.7 -66.4 -33.9 -17.1 -26.2 24.2 95 256 A S H >< S+ 0 0 11 -4,-1.8 3,-2.5 -5,-0.3 117,-0.3 0.551 80.6 124.0 -85.8 -9.1 -14.0 -24.5 22.6 96 257 A Y T << S+ 0 0 90 -4,-0.8 117,-0.2 -3,-0.6 3,-0.1 -0.338 85.0 6.2 -62.3 121.9 -12.5 -23.4 26.0 97 258 A G T 3 S+ 0 0 43 115,-3.4 -1,-0.3 1,-0.3 2,-0.2 0.429 100.7 131.6 86.2 -0.2 -9.0 -24.8 26.2 98 259 A K < - 0 0 121 -3,-2.5 114,-2.8 114,-0.3 -1,-0.3 -0.547 56.6-116.3 -88.6 152.8 -9.0 -26.2 22.6 99 260 A A E +D 211 0A 60 112,-0.2 2,-0.3 -2,-0.2 112,-0.2 -0.631 33.4 176.6 -89.1 143.6 -6.2 -25.6 20.0 100 261 A F E -D 210 0A 14 110,-2.8 110,-2.6 -2,-0.3 2,-0.5 -0.930 27.0-129.2-137.3 158.9 -6.8 -23.7 16.8 101 262 A K E -D 209 0A 151 -2,-0.3 2,-0.3 108,-0.2 20,-0.2 -0.971 24.6-161.4-109.7 126.7 -4.7 -22.6 13.9 102 263 A L E -D 208 0A 0 106,-2.9 106,-2.7 -2,-0.5 2,-0.5 -0.819 10.4-137.1-107.0 148.3 -4.9 -18.9 12.9 103 264 A S E -DE 207 119A 18 16,-0.8 16,-2.7 -2,-0.3 2,-0.6 -0.912 8.0-155.2-107.4 124.4 -3.9 -17.5 9.6 104 265 A I E +DE 206 118A 0 102,-3.2 102,-1.9 -2,-0.5 14,-0.2 -0.886 17.3 172.2 -97.3 121.8 -1.9 -14.1 9.4 105 266 A S E + 0 0 13 12,-2.0 97,-1.9 -2,-0.6 2,-0.3 0.646 59.5 8.6-105.0 -20.1 -2.5 -12.4 6.0 106 267 A A E -DE 201 117A 2 11,-0.8 11,-3.0 95,-0.2 2,-0.3 -0.995 53.3-141.8-158.0 153.4 -0.8 -9.0 6.5 107 268 A L E -DE 200 116A 1 93,-2.0 93,-3.2 -2,-0.3 2,-0.3 -0.908 29.3-174.1-111.5 149.1 1.3 -6.9 8.8 108 269 A F E -DE 199 115A 3 7,-2.4 7,-2.1 -2,-0.3 2,-0.4 -0.981 16.2-162.0-145.7 158.8 0.6 -3.2 9.2 109 270 A V E +DE 198 114A 0 89,-2.3 89,-2.7 -2,-0.3 5,-0.2 -0.998 11.9 169.0-139.5 137.1 1.9 -0.1 10.8 110 271 A T - 0 0 4 3,-2.6 87,-0.2 -2,-0.4 86,-0.1 -0.843 55.5 -92.0-132.6 174.5 0.2 3.3 11.6 111 272 A P S S+ 0 0 33 0, 0.0 3,-0.1 0, 0.0 85,-0.1 0.664 126.8 36.8 -61.7 -10.3 1.4 6.2 13.7 112 273 A K S S+ 0 0 98 1,-0.3 42,-2.6 41,-0.1 2,-0.3 0.788 121.1 11.4-109.2 -41.1 -0.4 4.5 16.6 113 274 A T E - F 0 153A 0 40,-0.2 -3,-2.6 48,-0.1 2,-0.4 -0.925 46.1-148.6-141.2 162.5 -0.0 0.8 16.4 114 275 A A E +EF 109 152A 4 38,-2.7 37,-2.8 -2,-0.3 38,-1.8 -0.999 38.8 143.9-128.1 133.2 1.7 -2.1 14.7 115 276 A G E -EF 108 150A 1 -7,-2.1 -7,-2.4 -2,-0.4 2,-0.4 -0.914 44.2-107.8-155.5-176.8 -0.1 -5.4 14.3 116 277 A A E -EF 107 149A 0 33,-2.4 33,-2.2 -2,-0.3 2,-0.5 -0.971 30.1-127.6-122.9 135.6 -0.9 -8.5 12.3 117 278 A Q E -EF 106 148A 32 -11,-3.0 -12,-2.0 -2,-0.4 -11,-0.8 -0.733 22.1-154.4 -83.1 129.6 -4.2 -9.1 10.5 118 279 A V E -E 104 0A 4 29,-2.2 2,-0.6 -2,-0.5 -14,-0.2 -0.874 3.9-158.6-104.7 133.6 -5.9 -12.4 11.3 119 280 A V E -E 103 0A 66 -16,-2.7 -16,-0.8 -2,-0.4 2,-0.2 -0.957 20.3-142.7-113.3 117.0 -8.2 -14.1 8.9 120 281 A L - 0 0 20 -2,-0.6 -18,-0.1 24,-0.2 2,-0.1 -0.467 4.6-127.5 -86.7 146.7 -10.5 -16.6 10.6 121 282 A T > - 0 0 63 -20,-0.2 4,-2.4 -2,-0.2 5,-0.1 -0.324 36.2-103.9 -71.9 168.8 -11.8 -19.9 9.4 122 283 A D H > S+ 0 0 134 2,-0.2 4,-0.8 1,-0.2 -1,-0.1 0.882 124.6 54.3 -64.5 -37.6 -15.5 -20.5 9.5 123 284 A Q H >4 S+ 0 0 124 1,-0.2 3,-0.7 2,-0.2 4,-0.3 0.921 111.5 45.4 -58.1 -44.9 -15.1 -22.7 12.7 124 285 A E H >4 S+ 0 0 3 1,-0.2 3,-2.1 2,-0.2 4,-0.2 0.849 101.5 64.9 -71.3 -35.6 -13.2 -19.8 14.3 125 286 A L H >< S+ 0 0 62 -4,-2.4 3,-1.4 1,-0.3 -1,-0.2 0.764 89.2 69.9 -56.8 -23.9 -15.8 -17.2 13.2 126 287 A Q T << S+ 0 0 107 -4,-0.8 -1,-0.3 -3,-0.7 -2,-0.2 0.759 99.1 48.9 -65.3 -22.3 -18.3 -19.0 15.5 127 288 A L T < S+ 0 0 1 -3,-2.1 -1,-0.3 -4,-0.3 -2,-0.2 0.339 87.8 104.9 -97.0 1.6 -16.2 -17.7 18.4 128 289 A W S < S- 0 0 42 -3,-1.4 -55,-0.1 -4,-0.2 -56,-0.1 -0.707 77.7-113.8 -83.4 134.8 -16.3 -14.1 17.1 129 290 A P - 0 0 16 0, 0.0 2,-0.4 0, 0.0 15,-0.2 -0.300 19.0-157.7 -69.3 152.4 -18.7 -11.9 19.0 130 291 A S + 0 0 108 -48,-0.1 2,-0.2 13,-0.1 4,-0.0 -0.923 25.6 177.6-124.5 104.7 -21.8 -10.4 17.5 131 292 A D - 0 0 45 -2,-0.4 3,-0.1 1,-0.1 -49,-0.1 -0.505 37.9-124.7-103.7 171.6 -22.8 -7.4 19.6 132 293 A L S S+ 0 0 181 1,-0.2 2,-0.8 -2,-0.2 -1,-0.1 0.957 100.1 56.1 -75.7 -57.0 -25.5 -4.7 19.5 133 294 A D S S- 0 0 149 -52,-0.0 -1,-0.2 0, 0.0 -2,-0.1 -0.705 77.1-177.6 -82.4 107.2 -23.3 -1.6 19.5 134 295 A K - 0 0 105 -2,-0.8 5,-0.1 -3,-0.1 -4,-0.0 -0.835 31.2 -97.6-111.2 146.3 -20.9 -2.0 16.6 135 296 A P > - 0 0 44 0, 0.0 3,-0.8 0, 0.0 4,-0.4 -0.218 21.7-136.5 -57.7 145.7 -18.0 0.3 15.5 136 297 A S G > S+ 0 0 102 1,-0.2 3,-0.8 2,-0.2 -2,-0.0 0.795 105.2 59.7 -73.0 -29.2 -18.8 2.8 12.7 137 298 A A G 3 S+ 0 0 37 1,-0.2 -1,-0.2 3,-0.0 34,-0.1 0.520 98.7 60.6 -76.5 -5.6 -15.5 2.0 11.0 138 299 A S G X S+ 0 0 28 -3,-0.8 3,-2.2 2,-0.1 -1,-0.2 0.629 74.3 121.1 -94.2 -15.8 -16.6 -1.7 10.7 139 300 A E T < S+ 0 0 145 -3,-0.8 -3,-0.0 -4,-0.4 0, 0.0 -0.192 78.9 16.2 -57.0 134.3 -19.7 -1.0 8.6 140 301 A G T 3 S+ 0 0 55 1,-0.3 -1,-0.3 34,-0.0 -2,-0.1 0.360 103.1 111.2 85.4 -5.3 -19.7 -2.8 5.2 141 302 A L S < S- 0 0 31 -3,-2.2 -1,-0.3 1,-0.1 3,-0.1 -0.808 75.0-102.9-103.5 144.1 -16.9 -5.1 6.4 142 303 A P > - 0 0 83 0, 0.0 3,-1.7 0, 0.0 -1,-0.1 -0.215 48.1 -84.6 -62.5 150.5 -17.5 -8.9 7.0 143 304 A P T 3 S+ 0 0 110 0, 0.0 -13,-0.1 0, 0.0 -18,-0.0 -0.209 117.0 28.5 -50.5 141.3 -17.8 -10.2 10.6 144 305 A G T > S+ 0 0 10 -15,-0.2 3,-1.4 -3,-0.1 -24,-0.2 0.476 78.0 126.7 84.2 2.1 -14.4 -10.9 12.2 145 306 A S T < + 0 0 20 -3,-1.7 -27,-0.1 1,-0.3 25,-0.1 0.784 67.8 61.6 -62.7 -27.0 -12.6 -8.2 10.1 146 307 A R T 3 S+ 0 0 75 -29,-0.1 -1,-0.3 20,-0.1 20,-0.1 0.690 73.8 124.7 -73.2 -18.2 -11.3 -6.7 13.3 147 308 A A < + 0 0 0 -3,-1.4 -29,-2.2 -29,-0.1 2,-0.3 -0.160 36.0 137.6 -52.2 126.2 -9.4 -9.9 14.3 148 309 A H E - F 0 117A 21 -77,-0.3 2,-0.5 -31,-0.2 -77,-0.4 -0.959 51.2-121.6-159.1 168.3 -5.7 -9.0 14.8 149 310 A V E - F 0 116A 0 -33,-2.2 -33,-2.4 -2,-0.3 2,-0.4 -0.995 30.2-133.2-122.9 123.3 -2.6 -9.6 16.9 150 311 A T E + F 0 115A 20 -81,-0.6 -81,-0.2 -2,-0.5 -35,-0.2 -0.606 28.0 171.9 -74.5 131.1 -1.1 -6.5 18.5 151 312 A L E - 0 0 29 -37,-2.8 2,-0.3 1,-0.4 -36,-0.2 0.635 63.2 -12.0-111.2 -23.5 2.7 -6.3 18.0 152 313 A G E - F 0 114A 1 -38,-1.8 -38,-2.7 -89,-0.2 -1,-0.4 -0.952 51.9-154.2-173.1 155.3 3.4 -2.8 19.3 153 314 A C E -CF 62 113A 4 -91,-2.2 -91,-1.8 -2,-0.3 -40,-0.2 -0.987 28.4-110.2-135.9 145.5 1.9 0.5 20.4 154 315 A A > - 0 0 7 -42,-2.6 3,-2.2 -2,-0.3 -94,-0.1 -0.306 50.2 -91.4 -65.2 162.4 3.1 4.1 20.5 155 316 A A T 3 S+ 0 0 83 -96,-0.4 -1,-0.1 1,-0.3 -43,-0.0 0.770 122.8 34.6 -52.0 -41.0 3.7 5.5 24.0 156 317 A D T 3 S+ 0 0 142 2,-0.1 2,-0.4 -44,-0.0 -1,-0.3 0.167 98.7 102.6-104.0 20.3 0.3 7.1 24.6 157 318 A V < - 0 0 12 -3,-2.2 -4,-0.1 -45,-0.1 -95,-0.0 -0.834 63.2-135.4-109.2 139.6 -1.8 4.5 22.7 158 319 A Q > - 0 0 124 -2,-0.4 3,-2.5 1,-0.1 4,-0.3 -0.733 24.0-119.6 -89.7 144.1 -3.9 1.7 24.1 159 320 A P T > S+ 0 0 71 0, 0.0 3,-1.8 0, 0.0 4,-0.4 0.735 108.8 69.9 -55.4 -28.7 -3.7 -1.8 22.5 160 321 A V T >> S+ 0 0 89 1,-0.3 4,-1.0 2,-0.2 3,-0.9 0.790 84.3 72.8 -61.0 -25.8 -7.4 -1.8 21.6 161 322 A Q H <> S+ 0 0 42 -3,-2.5 4,-2.8 1,-0.2 -1,-0.3 0.779 81.0 72.6 -59.4 -26.4 -6.5 0.8 19.1 162 323 A T H <> S+ 0 0 0 -3,-1.8 4,-2.3 -4,-0.3 -1,-0.2 0.896 96.3 48.4 -59.2 -41.7 -4.8 -1.8 16.9 163 324 A G H <> S+ 0 0 0 -3,-0.9 4,-2.3 -4,-0.4 -1,-0.2 0.871 111.5 49.6 -66.3 -38.8 -8.2 -3.3 15.9 164 325 A L H X S+ 0 0 59 -4,-1.0 4,-2.2 2,-0.2 -2,-0.2 0.906 110.2 51.5 -64.9 -40.5 -9.6 0.1 15.0 165 326 A D H X S+ 0 0 16 -4,-2.8 4,-2.2 2,-0.2 -2,-0.2 0.909 109.3 50.2 -62.9 -41.5 -6.5 0.8 13.0 166 327 A L H X S+ 0 0 1 -4,-2.3 4,-2.9 1,-0.2 5,-0.2 0.944 109.3 50.6 -62.0 -46.9 -6.9 -2.5 11.1 167 328 A L H X S+ 0 0 2 -4,-2.3 4,-2.5 1,-0.2 -1,-0.2 0.893 109.2 52.4 -57.5 -39.7 -10.6 -1.7 10.4 168 329 A D H X S+ 0 0 63 -4,-2.2 4,-1.8 2,-0.2 -1,-0.2 0.922 110.7 46.9 -63.6 -44.1 -9.5 1.7 9.0 169 330 A I H X S+ 0 0 1 -4,-2.2 4,-2.3 2,-0.2 -2,-0.2 0.922 111.8 50.5 -61.6 -46.0 -7.0 0.1 6.7 170 331 A L H X S+ 0 0 22 -4,-2.9 4,-2.6 1,-0.2 -2,-0.2 0.883 107.2 55.0 -61.7 -37.9 -9.5 -2.5 5.5 171 332 A Q H X S+ 0 0 48 -4,-2.5 4,-1.7 -5,-0.2 -1,-0.2 0.903 108.6 48.6 -59.1 -41.9 -12.0 0.3 4.8 172 333 A Q H <>S+ 0 0 49 -4,-1.8 5,-2.8 2,-0.2 6,-0.4 0.908 112.1 47.8 -64.3 -44.1 -9.4 2.0 2.6 173 334 A V H ><5S+ 0 0 46 -4,-2.3 3,-1.5 1,-0.2 5,-0.2 0.883 107.5 56.8 -65.0 -38.3 -8.7 -1.2 0.7 174 335 A K H 3<5S+ 0 0 123 -4,-2.6 -1,-0.2 1,-0.3 -2,-0.2 0.902 107.8 47.9 -57.6 -42.3 -12.4 -1.8 0.3 175 336 A G T 3<5S- 0 0 61 -4,-1.7 -1,-0.3 -5,-0.2 -2,-0.2 0.422 117.7-115.6 -79.6 1.6 -12.7 1.5 -1.4 176 337 A G T < 5S+ 0 0 58 -3,-1.5 3,-0.3 -4,-0.2 -3,-0.2 0.811 80.4 126.9 67.4 30.6 -9.7 0.7 -3.6 177 338 A S < + 0 0 67 -5,-2.8 -4,-0.2 1,-0.2 -5,-0.1 0.313 41.7 99.0 -95.3 5.8 -7.6 3.4 -2.1 178 339 A Q S S- 0 0 47 -6,-0.4 14,-0.2 -5,-0.2 -1,-0.2 0.860 72.7-166.1 -60.3 -38.7 -4.9 0.8 -1.4 179 340 A G - 0 0 47 -3,-0.3 2,-0.1 12,-0.1 -1,-0.1 0.004 31.0 -35.3 79.7 175.3 -3.1 1.9 -4.5 180 341 A E S S- 0 0 177 1,-0.1 12,-0.4 11,-0.1 0, 0.0 -0.432 77.1 -92.5 -66.7 142.8 -0.3 0.4 -6.5 181 342 A A - 0 0 25 1,-0.1 10,-0.2 10,-0.1 -1,-0.1 -0.316 33.2-161.5 -55.5 138.8 2.3 -1.5 -4.4 182 343 A V + 0 0 64 8,-2.8 2,-0.3 1,-0.2 -144,-0.2 0.307 66.6 14.0-108.7 7.8 5.2 0.9 -3.4 183 344 A G E -G 190 0A 9 7,-0.9 7,-2.6 -145,-0.1 2,-0.5 -0.973 59.0-131.7-173.4 160.4 7.7 -1.8 -2.5 184 345 A E E -G 189 0A 137 -2,-0.3 5,-0.2 5,-0.2 -3,-0.0 -0.876 28.0-176.6-125.4 96.7 8.6 -5.5 -2.7 185 346 A L E > -G 188 0A 21 3,-2.1 3,-1.1 -2,-0.5 -2,-0.0 -0.550 43.2-102.5 -88.9 158.8 9.7 -6.9 0.7 186 347 A P T 3 S+ 0 0 111 0, 0.0 -1,-0.1 0, 0.0 3,-0.1 0.754 122.3 41.5 -50.6 -28.2 11.0 -10.5 1.1 187 348 A R T 3 S- 0 0 112 1,-0.2 16,-3.0 16,-0.1 17,-0.5 0.616 125.9 -53.1 -98.1 -15.8 7.6 -11.5 2.6 188 349 A G E < S-GH 185 202A 4 -3,-1.1 -3,-2.1 14,-0.3 2,-0.3 -0.994 73.5 -36.4 169.7-168.7 5.2 -9.6 0.3 189 350 A K E -GH 184 201A 105 12,-1.1 12,-2.4 -2,-0.3 2,-0.5 -0.629 48.3-138.6 -84.5 136.2 4.0 -6.4 -1.4 190 351 A L E -GH 183 200A 0 -7,-2.6 -8,-2.8 -2,-0.3 -7,-0.9 -0.822 17.6-164.7 -96.8 129.7 4.3 -3.1 0.6 191 352 A Y E - H 0 199A 30 8,-3.2 8,-2.3 -2,-0.5 2,-0.6 -0.938 12.6-150.9-116.7 136.0 1.4 -0.7 0.3 192 353 A S E + H 0 198A 37 -12,-0.4 6,-0.2 -2,-0.4 3,-0.1 -0.920 15.7 177.1-102.1 116.2 1.3 3.0 1.3 193 354 A L E - 0 0 9 4,-2.6 5,-0.2 -2,-0.6 -1,-0.1 0.417 40.9-119.0-100.7 0.8 -2.2 4.0 2.3 194 355 A G E > S+ H 0 197A 34 3,-0.7 3,-1.9 -16,-0.1 -1,-0.3 -0.077 88.1 72.3 81.9 171.6 -1.5 7.5 3.4 195 356 A K T 3 S- 0 0 162 1,-0.3 3,-0.1 -3,-0.1 -1,-0.0 0.821 131.7 -58.9 48.7 36.8 -1.9 9.2 6.8 196 357 A G T 3 S+ 0 0 3 1,-0.2 2,-0.4 -86,-0.1 -1,-0.3 0.601 102.8 138.6 77.6 13.4 1.1 7.2 8.0 197 358 A R E < +H 194 0A 16 -3,-1.9 -4,-2.6 -87,-0.2 -3,-0.7 -0.780 25.8 177.0-102.8 134.2 -0.5 3.9 7.3 198 359 A W E -HD 192 109A 4 -89,-2.7 -89,-2.3 -2,-0.4 2,-0.4 -0.991 8.3-167.1-137.7 140.6 1.4 1.0 5.8 199 360 A M E -HD 191 108A 9 -8,-2.3 -8,-3.2 -2,-0.4 2,-0.6 -0.993 10.2-159.7-135.2 132.8 0.5 -2.6 4.9 200 361 A L E -HD 190 107A 2 -93,-3.2 -93,-2.0 -2,-0.4 2,-0.7 -0.947 14.6-153.3-106.3 113.4 2.5 -5.7 4.0 201 362 A S E -HD 189 106A 36 -12,-2.4 -12,-1.1 -2,-0.6 -95,-0.2 -0.805 21.6-128.0 -88.2 115.2 0.4 -8.3 2.2 202 363 A L E -H 188 0A 13 -97,-1.9 -14,-0.3 -2,-0.7 3,-0.2 -0.402 8.1-151.8 -67.1 130.3 2.1 -11.6 2.9 203 364 A T E S+ 0 0 123 -16,-3.0 2,-0.5 1,-0.3 -1,-0.2 0.919 94.4 30.3 -63.6 -43.6 2.8 -13.7 -0.2 204 365 A K E S- 0 0 164 -17,-0.5 -1,-0.3 -3,-0.0 2,-0.1 -0.979 95.3-122.8-118.6 122.6 2.4 -16.8 1.9 205 366 A K E - 0 0 108 -2,-0.5 2,-0.5 -3,-0.2 -100,-0.2 -0.399 25.0-126.3 -63.3 139.1 0.0 -16.6 4.9 206 367 A M E - D 0 104A 15 -102,-1.9 -102,-3.2 -2,-0.1 2,-0.5 -0.753 18.9-146.9 -89.2 130.1 1.7 -17.4 8.2 207 368 A E E - D 0 103A 101 -2,-0.5 2,-0.4 -104,-0.2 -104,-0.2 -0.835 16.3-172.5 -98.5 131.9 0.0 -20.1 10.3 208 369 A V E - D 0 102A 2 -106,-2.7 -106,-2.9 -2,-0.5 2,-0.4 -0.968 19.0-133.4-123.7 142.5 0.1 -19.8 14.0 209 370 A K E + D 0 101A 113 -2,-0.4 -194,-2.3 -108,-0.2 2,-0.3 -0.776 34.4 168.3 -90.3 138.3 -1.0 -22.3 16.7 210 371 A A E -BD 14 100A 0 -110,-2.6 -110,-2.8 -2,-0.4 2,-0.5 -0.972 31.6-130.6-147.4 156.6 -3.1 -20.9 19.5 211 372 A I E -BD 13 99A 58 -198,-2.6 -198,-2.8 -2,-0.3 2,-0.6 -0.950 23.1-132.4-109.7 130.6 -5.2 -22.0 22.5 212 373 A F E +B 12 0A 0 -114,-2.8 -115,-3.4 -2,-0.5 -114,-0.3 -0.694 53.8 122.9 -79.8 122.3 -8.7 -20.5 22.9 213 374 A T E -B 11 0A 41 -202,-2.7 -202,-2.3 -2,-0.6 2,-0.4 -0.877 57.7 -84.9-161.2-171.9 -9.1 -19.5 26.6 214 375 A G E -B 10 0A 11 -2,-0.3 2,-0.4 -204,-0.2 -204,-0.2 -0.929 26.3-149.4-117.2 134.8 -9.8 -16.6 29.0 215 376 A Y E -B 9 0A 100 -206,-2.9 -207,-2.5 -2,-0.4 -206,-1.5 -0.864 11.8-177.6-102.3 136.2 -7.3 -14.1 30.4 216 377 A Y 0 0 99 -2,-0.4 -1,-0.1 -209,-0.2 -210,-0.0 0.459 360.0 360.0-114.8 -4.9 -7.9 -12.7 33.9 217 378 A G 0 0 95 -210,-0.0 -2,-0.0 0, 0.0 0, 0.0 0.898 360.0 360.0 70.3 360.0 -5.1 -10.2 34.4