HEADER    CHAPERONE                               04-JUN-07   XXXX              
TITLE     CRYSTAL STRUCTURE OF SPCIA1/ASF1 COMPLEXED WITH CAC2 PEPTIDE          
COMPND    Histone chaperone cia1, SPAC26H5.03 protein                           
KEYWDS    HISTONE CHAPERONE, NUCLEOSOME DIASSEMBLY/ASSEMBLY,                    
KEYWDS   2 CHROMATIN REGULATION, CHROMATIN REGULATOR, COILED COIL,              
KEYWDS   3 NUCLEUS, TRANSCRIPTION, TRANSCRIPTION REGULATION, WD REPEAT,         
KEYWDS   4 STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN             
KEYWDS   5 STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL                 
KEYWDS   6 GENOMICS/PROTEOMICS INITIATIVE, RSGI                                 
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    A.D.MALAY, B.PADMANABHAN, S.YOKOYAMA, RIKEN STRUCTURAL                
AUTHOR   2 GENOMICS/PROTEOMICS INITIATIVE (RSGI)                                
JRNL        AUTH   A.D.MALAY, T.UMEHARA, K.MATSUBARA-MALAY,                     
JRNL        AUTH 2 B.PADMANABHAN, S.YOKOYAMA                                    
JRNL        TITL   CRYSTAL STRUCTURES OF FISSION YEAST HISTONE                  
JRNL        TITL 2 CHAPERONE ASF1 COMPLEXED WITH THE HIP1 B-DOMAIN OR           
JRNL        TITL 3 THE CAC2 C TERMINUS                                          
JRNL        REF    J.BIOL.CHEM.                  V. 283 14022 2008              
JRNL        REFN   ASTM JBCHA3  US ISSN 0021-9258                               
JRNL        PMID   18334479                                                     
JRNL        DOI    10.1074/JBC.M800594200                                       
SEQRES   1 A  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 A  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 A  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 A  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 A  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 A  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 A  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 A  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 A  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 A  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 A  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 A  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 A  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 I   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 I   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 B  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 B  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 B  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 B  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 B  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 B  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 B  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 B  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 B  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 B  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 B  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 B  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 B  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 J   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 J   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 C  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 C  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 C  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 C  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 C  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 C  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 C  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 C  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 C  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 C  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 C  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 C  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 C  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 K   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 K   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 D  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 D  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 D  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 D  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 D  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 D  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 D  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 D  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 D  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 D  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 D  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 D  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 D  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 L   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 L   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 E  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 E  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 E  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 E  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 E  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 E  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 E  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 E  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 E  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 E  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 E  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 E  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 E  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 M   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 M   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 F  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 F  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 F  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 F  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 F  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 F  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 F  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 F  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 F  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 F  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 F  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 F  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 F  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 N   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 N   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 G  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 G  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 G  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 G  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 G  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 G  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 G  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 G  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 G  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 G  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 G  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 G  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 G  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 O   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 O   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 H  161  MET SER ILE VAL ASN ILE LEU SER VAL ASN VAL LEU ASN          
SEQRES   2 H  161  ASN PRO ALA LYS PHE SER ASP PRO TYR LYS PHE GLU ILE          
SEQRES   3 H  161  THR PHE GLU CYS LEU GLU PRO LEU LYS SER ASP LEU GLU          
SEQRES   4 H  161  TRP LYS LEU THR TYR VAL GLY SER ALA THR SER GLN SER          
SEQRES   5 H  161  TYR ASP GLN ILE LEU ASP THR LEU LEU VAL GLY PRO ILE          
SEQRES   6 H  161  PRO ILE GLY ILE ASN LYS PHE VAL PHE GLU ALA ASP PRO          
SEQRES   7 H  161  PRO ASN ILE ASP LEU LEU PRO GLN LEU SER ASP VAL LEU          
SEQRES   8 H  161  GLY VAL THR VAL ILE LEU LEU SER CYS ALA TYR GLU ASP          
SEQRES   9 H  161  ASN GLU PHE VAL ARG VAL GLY TYR TYR VAL ASN ASN GLU          
SEQRES  10 H  161  MET GLU GLY LEU ASN LEU GLN GLU MET ASP ASP ALA GLU          
SEQRES  11 H  161  ILE LYS LYS VAL LYS VAL ASP ILE SER LYS VAL TRP ARG          
SEQRES  12 H  161  SER ILE LEU ALA GLU LYS PRO ARG VAL THR ARG PHE ASN          
SEQRES  13 H  161  ILE GLN TRP ASP ASN                                          
SEQRES   1 P   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 P   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 Q   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 Q   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 R   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 R   20  ALA PRO THR PRO VAL TYR PRO                                  
SEQRES   1 T   20  ARG LYS VAL GLU SER SER LYS VAL SER LYS LYS ARG ILE          
SEQRES   2 T   20  ALA PRO THR PRO VAL TYR PRO                                  
FORMUL  20  HOH   *312(H2 O)                                                    
HELIX    1   1 SER A   50  ASP A   54  5                                   5    
HELIX    2   2 ASN A   80  LEU A   84  5                                   5    
HELIX    3   3 GLN A   86  LEU A   91  5                                   6    
HELIX    4   4 ASP A  127  VAL A  134  1                                   8    
HELIX    5   5 ASP A  137  SER A  139  5                                   3    
HELIX    6   6 SER B   50  ASP B   54  5                                   5    
HELIX    7   7 ASN B   80  LEU B   84  5                                   5    
HELIX    8   8 GLN B   86  LEU B   91  5                                   6    
HELIX    9   9 ASP B  127  LYS B  133  1                                   7    
HELIX   10  10 ASP B  137  SER B  139  5                                   3    
HELIX   11  11 SER C   50  SER C   52  5                                   3    
HELIX   12  12 ASN C   80  LEU C   84  5                                   5    
HELIX   13  13 GLN C   86  LEU C   91  5                                   6    
HELIX   14  14 ASP C  127  LYS C  133  1                                   7    
HELIX   15  15 ASP C  137  SER C  139  5                                   3    
HELIX   16  16 SER D   50  ASP D   54  5                                   5    
HELIX   17  17 ASN D   80  LEU D   84  5                                   5    
HELIX   18  18 GLN D   86  LEU D   91  5                                   6    
HELIX   19  19 ASP D  127  LYS D  133  1                                   7    
HELIX   20  20 ASP D  137  SER D  139  5                                   3    
HELIX   21  21 SER E   50  ASP E   54  5                                   5    
HELIX   22  22 ASN E   80  LEU E   84  5                                   5    
HELIX   23  23 GLN E   86  LEU E   91  5                                   6    
HELIX   24  24 ASP E  127  LYS E  133  1                                   7    
HELIX   25  25 ASP E  137  SER E  139  5                                   3    
HELIX   26  26 SER F   50  ASP F   54  5                                   5    
HELIX   27  27 ASN F   80  LEU F   84  5                                   5    
HELIX   28  28 GLN F   86  LEU F   91  5                                   6    
HELIX   29  29 ASN F  122  MET F  126  5                                   5    
HELIX   30  30 ASP F  127  VAL F  134  1                                   8    
HELIX   31  31 ASP F  137  SER F  139  5                                   3    
HELIX   32  32 ASN G   80  LEU G   84  5                                   5    
HELIX   33  33 GLN G   86  LEU G   91  5                                   6    
HELIX   34  34 ASP G  127  VAL G  134  1                                   8    
HELIX   35  35 ASP G  137  SER G  139  5                                   3    
HELIX   36  36 ASN H   80  LEU H   84  5                                   5    
HELIX   37  37 GLN H   86  LEU H   91  5                                   6    
HELIX   38  38 ASP H  127  VAL H  134  1                                   8    
HELIX   39  39 ASP H  137  SER H  139  5                                   3    
SHEET    1   A 4 VAL A   4  VAL A  11  0                                        
SHEET    2   A 4 TYR A  22  CYS A  30 -1  O  THR A  27   N  LEU A   7           
SHEET    3   A 4 GLY A  68  ALA A  76 -1  O  PHE A  74   N  PHE A  24           
SHEET    4   A 4 THR I 508  TYR I 511 -1  O  THR I 508   N  LYS A  71           
SHEET    1   B 4 ALA A  16  LYS A  17  0                                        
SHEET    2   B 4 VAL A 141  ILE A 145 -1  O  ARG A 143   N  ALA A  16           
SHEET    3   B 4 ASN A 105  MET A 118 -1  N  GLU A 117   O  TRP A 142           
SHEET    4   B 4 ARG A 151  ARG A 154 -1  O  THR A 153   N  ARG A 109           
SHEET    1   C 7 ALA A  16  LYS A  17  0                                        
SHEET    2   C 7 VAL A 141  ILE A 145 -1  O  ARG A 143   N  ALA A  16           
SHEET    3   C 7 ASN A 105  MET A 118 -1  N  GLU A 117   O  TRP A 142           
SHEET    4   C 7 GLY A  92  TYR A 102 -1  N  LEU A  98   O  VAL A 110           
SHEET    5   C 7 LEU A  38  VAL A  45 -1  N  GLU A  39   O  ALA A 101           
SHEET    6   C 7 GLN A  55  VAL A  62 -1  O  VAL A  62   N  LEU A  38           
SHEET    7   C 7 ARG I 504  ILE I 505  1  O  ILE I 505   N  LEU A  61           
SHEET    1   D 4 VAL B   4  VAL B  11  0                                        
SHEET    2   D 4 TYR B  22  CYS B  30 -1  O  THR B  27   N  LEU B   7           
SHEET    3   D 4 GLY B  68  ALA B  76 -1  O  GLY B  68   N  CYS B  30           
SHEET    4   D 4 THR J 508  TYR J 511 -1  O  THR J 508   N  LYS B  71           
SHEET    1   E 4 ALA B  16  LYS B  17  0                                        
SHEET    2   E 4 VAL B 141  ILE B 145 -1  O  ARG B 143   N  ALA B  16           
SHEET    3   E 4 GLU B 106  MET B 118 -1  N  GLU B 117   O  TRP B 142           
SHEET    4   E 4 ARG B 151  ARG B 154 -1  O  ARG B 151   N  GLY B 111           
SHEET    1   F 7 ALA B  16  LYS B  17  0                                        
SHEET    2   F 7 VAL B 141  ILE B 145 -1  O  ARG B 143   N  ALA B  16           
SHEET    3   F 7 GLU B 106  MET B 118 -1  N  GLU B 117   O  TRP B 142           
SHEET    4   F 7 GLY B  92  TYR B 102 -1  N  THR B  94   O  VAL B 114           
SHEET    5   F 7 LEU B  38  VAL B  45 -1  N  GLU B  39   O  ALA B 101           
SHEET    6   F 7 GLN B  55  VAL B  62 -1  O  LEU B  60   N  TRP B  40           
SHEET    7   F 7 ARG J 504  ILE J 505  1  O  ILE J 505   N  LEU B  61           
SHEET    1   G 4 VAL C   4  VAL C  11  0                                        
SHEET    2   G 4 TYR C  22  CYS C  30 -1  O  GLU C  25   N  ASN C  10           
SHEET    3   G 4 GLY C  68  ALA C  76 -1  O  GLY C  68   N  CYS C  30           
SHEET    4   G 4 THR K 508  PRO K 509 -1  O  THR K 508   N  LYS C  71           
SHEET    1   H 6 ALA C  16  LYS C  17  0                                        
SHEET    2   H 6 VAL C 141  ILE C 145 -1  O  ARG C 143   N  ALA C  16           
SHEET    3   H 6 GLU C 106  MET C 118 -1  N  GLU C 117   O  TRP C 142           
SHEET    4   H 6 GLY C  92  TYR C 102 -1  N  LEU C  98   O  VAL C 110           
SHEET    5   H 6 LEU C  38  VAL C  45 -1  N  GLU C  39   O  ALA C 101           
SHEET    6   H 6 ASP C  54  VAL C  62 -1  O  VAL C  62   N  LEU C  38           
SHEET    1   I 4 ALA C  16  LYS C  17  0                                        
SHEET    2   I 4 VAL C 141  ILE C 145 -1  O  ARG C 143   N  ALA C  16           
SHEET    3   I 4 GLU C 106  MET C 118 -1  N  GLU C 117   O  TRP C 142           
SHEET    4   I 4 ARG C 151  ARG C 154 -1  O  ARG C 151   N  GLY C 111           
SHEET    1   J 4 VAL D   4  VAL D  11  0                                        
SHEET    2   J 4 TYR D  22  CYS D  30 -1  O  GLU D  29   N  ASN D   5           
SHEET    3   J 4 GLY D  68  ALA D  76 -1  O  PHE D  74   N  PHE D  24           
SHEET    4   J 4 THR L 508  PRO L 509 -1  O  THR L 508   N  LYS D  71           
SHEET    1   K 6 ALA D  16  LYS D  17  0                                        
SHEET    2   K 6 VAL D 141  ILE D 145 -1  O  ARG D 143   N  ALA D  16           
SHEET    3   K 6 GLU D 106  MET D 118 -1  N  GLU D 117   O  TRP D 142           
SHEET    4   K 6 GLY D  92  TYR D 102 -1  N  LEU D  98   O  VAL D 110           
SHEET    5   K 6 LEU D  38  VAL D  45 -1  N  GLU D  39   O  ALA D 101           
SHEET    6   K 6 GLN D  55  VAL D  62 -1  O  LEU D  60   N  TRP D  40           
SHEET    1   L 4 ALA D  16  LYS D  17  0                                        
SHEET    2   L 4 VAL D 141  ILE D 145 -1  O  ARG D 143   N  ALA D  16           
SHEET    3   L 4 GLU D 106  MET D 118 -1  N  GLU D 117   O  TRP D 142           
SHEET    4   L 4 ARG D 151  ARG D 154 -1  O  ARG D 151   N  GLY D 111           
SHEET    1   M 4 VAL E   4  VAL E  11  0                                        
SHEET    2   M 4 TYR E  22  CYS E  30 -1  O  THR E  27   N  LEU E   7           
SHEET    3   M 4 GLY E  68  ALA E  76 -1  O  GLY E  68   N  CYS E  30           
SHEET    4   M 4 THR M 508  TYR M 511 -1  O  THR M 508   N  LYS E  71           
SHEET    1   N 4 ALA E  16  LYS E  17  0                                        
SHEET    2   N 4 VAL E 141  ILE E 145 -1  O  ARG E 143   N  ALA E  16           
SHEET    3   N 4 GLU E 106  MET E 118 -1  N  GLU E 117   O  TRP E 142           
SHEET    4   N 4 ARG E 151  ARG E 154 -1  O  ARG E 151   N  GLY E 111           
SHEET    1   O 7 ALA E  16  LYS E  17  0                                        
SHEET    2   O 7 VAL E 141  ILE E 145 -1  O  ARG E 143   N  ALA E  16           
SHEET    3   O 7 GLU E 106  MET E 118 -1  N  GLU E 117   O  TRP E 142           
SHEET    4   O 7 GLY E  92  TYR E 102 -1  N  THR E  94   O  VAL E 114           
SHEET    5   O 7 LEU E  38  VAL E  45 -1  N  GLU E  39   O  ALA E 101           
SHEET    6   O 7 GLN E  55  VAL E  62 -1  O  GLN E  55   N  TYR E  44           
SHEET    7   O 7 ARG M 504  ILE M 505  1  O  ILE M 505   N  LEU E  61           
SHEET    1   P 4 VAL F   4  VAL F  11  0                                        
SHEET    2   P 4 TYR F  22  CYS F  30 -1  O  THR F  27   N  SER F   8           
SHEET    3   P 4 GLY F  68  ALA F  76 -1  O  ALA F  76   N  TYR F  22           
SHEET    4   P 4 THR N 508  TYR N 511 -1  O  TYR N 511   N  ILE F  69           
SHEET    1   Q 4 ALA F  16  LYS F  17  0                                        
SHEET    2   Q 4 VAL F 141  ILE F 145 -1  O  ARG F 143   N  ALA F  16           
SHEET    3   Q 4 GLU F 106  MET F 118 -1  N  ASN F 115   O  SER F 144           
SHEET    4   Q 4 ARG F 151  ARG F 154 -1  O  ARG F 151   N  GLY F 111           
SHEET    1   R 7 ALA F  16  LYS F  17  0                                        
SHEET    2   R 7 VAL F 141  ILE F 145 -1  O  ARG F 143   N  ALA F  16           
SHEET    3   R 7 GLU F 106  MET F 118 -1  N  ASN F 115   O  SER F 144           
SHEET    4   R 7 GLY F  92  TYR F 102 -1  N  LEU F  98   O  VAL F 110           
SHEET    5   R 7 LEU F  38  VAL F  45 -1  N  GLU F  39   O  ALA F 101           
SHEET    6   R 7 GLN F  55  VAL F  62 -1  O  VAL F  62   N  LEU F  38           
SHEET    7   R 7 ARG N 504  ILE N 505  1  O  ILE N 505   N  LEU F  61           
SHEET    1   S 4 VAL G   4  VAL G  11  0                                        
SHEET    2   S 4 TYR G  22  CYS G  30 -1  O  GLU G  29   N  ASN G   5           
SHEET    3   S 4 GLY G  68  ALA G  76 -1  O  ALA G  76   N  TYR G  22           
SHEET    4   S 4 THR O 508  PRO O 509 -1  O  THR O 508   N  LYS G  71           
SHEET    1   T 4 ALA G  16  LYS G  17  0                                        
SHEET    2   T 4 VAL G 141  ILE G 145 -1  O  ARG G 143   N  ALA G  16           
SHEET    3   T 4 ASN G 105  MET G 118 -1  N  GLU G 117   O  TRP G 142           
SHEET    4   T 4 ARG G 151  ARG G 154 -1  O  THR G 153   N  ARG G 109           
SHEET    1   U 7 ALA G  16  LYS G  17  0                                        
SHEET    2   U 7 VAL G 141  ILE G 145 -1  O  ARG G 143   N  ALA G  16           
SHEET    3   U 7 ASN G 105  MET G 118 -1  N  GLU G 117   O  TRP G 142           
SHEET    4   U 7 THR G  94  TYR G 102 -1  N  LEU G  98   O  VAL G 110           
SHEET    5   U 7 LEU G  38  VAL G  45 -1  N  LYS G  41   O  SER G  99           
SHEET    6   U 7 ASP G  54  VAL G  62 -1  O  VAL G  62   N  LEU G  38           
SHEET    7   U 7 ARG O 504  ILE O 505  1  O  ILE O 505   N  LEU G  61           
SHEET    1   V 4 VAL H   4  VAL H  11  0                                        
SHEET    2   V 4 TYR H  22  CYS H  30 -1  O  GLU H  25   N  ASN H  10           
SHEET    3   V 4 GLY H  68  ALA H  76 -1  O  ALA H  76   N  TYR H  22           
SHEET    4   V 4 THR P 508  PRO P 509 -1  O  THR P 508   N  LYS H  71           
SHEET    1   W 4 ALA H  16  LYS H  17  0                                        
SHEET    2   W 4 VAL H 141  ILE H 145 -1  O  ARG H 143   N  ALA H  16           
SHEET    3   W 4 ASN H 105  MET H 118 -1  N  GLU H 117   O  TRP H 142           
SHEET    4   W 4 ARG H 151  ARG H 154 -1  O  ARG H 151   N  GLY H 111           
SHEET    1   X 7 ALA H  16  LYS H  17  0                                        
SHEET    2   X 7 VAL H 141  ILE H 145 -1  O  ARG H 143   N  ALA H  16           
SHEET    3   X 7 ASN H 105  MET H 118 -1  N  GLU H 117   O  TRP H 142           
SHEET    4   X 7 THR H  94  TYR H 102 -1  N  LEU H  98   O  VAL H 110           
SHEET    5   X 7 LEU H  38  VAL H  45 -1  N  GLU H  39   O  ALA H 101           
SHEET    6   X 7 ASP H  54  VAL H  62 -1  O  LEU H  60   N  TRP H  40           
SHEET    7   X 7 ARG P 504  ILE P 505  1  O  ILE P 505   N  LEU H  61           
CISPEP   1 ASN A   14    PRO A   15          1         2.82                     
CISPEP   2 GLY A   63    PRO A   64          1        -2.69                     
CISPEP   3 TYR I  511    PRO I  512          1       -11.91                     
CISPEP   4 ASN B   14    PRO B   15          1         0.74                     
CISPEP   5 GLY B   63    PRO B   64          1         3.53                     
CISPEP   6 TYR J  511    PRO J  512          1        -3.48                     
CISPEP   7 ASN C   14    PRO C   15          1         1.83                     
CISPEP   8 GLY C   63    PRO C   64          1        -6.48                     
CISPEP   9 ASN D   14    PRO D   15          1         5.59                     
CISPEP  10 GLY D   63    PRO D   64          1        -8.32                     
CISPEP  11 TYR L  511    PRO L  512          1         9.02                     
CISPEP  12 ASN E   14    PRO E   15          1        -0.07                     
CISPEP  13 GLY E   63    PRO E   64          1         1.57                     
CISPEP  14 TYR M  511    PRO M  512          1         0.95                     
CISPEP  15 ASN F   14    PRO F   15          1        -3.78                     
CISPEP  16 GLY F   63    PRO F   64          1        -1.74                     
CISPEP  17 TYR N  511    PRO N  512          1         2.44                     
CISPEP  18 ASN G   14    PRO G   15          1         4.28                     
CISPEP  19 GLY G   63    PRO G   64          1        -0.21                     
CISPEP  20 TYR O  511    PRO O  512          1        12.98                     
CISPEP  21 ASN H   14    PRO H   15          1        -1.96                     
CISPEP  22 GLY H   63    PRO H   64          1        -6.39                     
CISPEP  23 TYR P  511    PRO P  512          1       -16.29                     
CRYST1  151.512  151.512  144.206  90.00  90.00  90.00 I 41         88          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.006600  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.006600  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006935        0.00000                         
MODEL        1                                                                  
ATOM      1  N   ARG K 504     139.334  43.045  35.805  1.00 51.52           N  
ATOM      2  CA  ARG K 504     140.660  43.687  35.644  1.00 52.40           C  
ATOM      3  C   ARG K 504     141.463  43.060  34.519  1.00 53.10           C  
ATOM      4  O   ARG K 504     141.412  41.844  34.359  1.00 53.69           O  
ATOM      5  CB  ARG K 504     141.465  43.505  36.903  1.00 52.58           C  
ATOM      6  CG  ARG K 504     142.978  43.583  36.706  1.00 53.72           C  
ATOM      7  CD  ARG K 504     143.703  44.355  37.803  1.00 55.94           C  
ATOM      8  NE  ARG K 504     145.161  44.283  37.628  1.00 57.94           N  
ATOM      9  CZ  ARG K 504     146.039  43.992  38.585  1.00 58.07           C  
ATOM     10  NH1 ARG K 504     147.326  43.961  38.291  1.00 58.24           N  
ATOM     11  NH2 ARG K 504     145.646  43.738  39.833  1.00 57.67           N  
ATOM     12  N   ILE K 505     142.228  43.865  33.769  1.00 53.02           N  
ATOM     13  CA  ILE K 505     143.075  43.356  32.687  1.00 53.32           C  
ATOM     14  C   ILE K 505     144.393  44.113  32.565  1.00 53.36           C  
ATOM     15  O   ILE K 505     144.568  45.196  33.142  1.00 53.59           O  
ATOM     16  CB  ILE K 505     142.356  43.486  31.303  1.00 53.97           C  
ATOM     17  CG1 ILE K 505     142.083  44.966  30.963  1.00 54.25           C  
ATOM     18  CG2 ILE K 505     141.071  42.632  31.223  1.00 54.62           C  
ATOM     19  CD1 ILE K 505     141.574  45.180  29.531  1.00 54.52           C  
ATOM     20  N   ALA K 506     145.308  43.607  31.753  1.00 52.68           N  
ATOM     21  CA  ALA K 506     146.489  44.404  31.544  1.00 52.76           C  
ATOM     22  C   ALA K 506     146.586  44.959  30.132  1.00 52.62           C  
ATOM     23  O   ALA K 506     146.146  44.371  29.148  1.00 52.04           O  
ATOM     24  CB  ALA K 506     147.753  43.649  31.935  1.00 52.85           C  
ATOM     25  N   PRO K 507     147.194  46.115  30.050  1.00 52.85           N  
ATOM     26  CA  PRO K 507     147.304  46.791  28.786  1.00 53.86           C  
ATOM     27  C   PRO K 507     148.401  46.154  28.039  1.00 55.11           C  
ATOM     28  O   PRO K 507     149.347  45.747  28.686  1.00 55.41           O  
ATOM     29  CB  PRO K 507     147.674  48.208  29.188  1.00 53.95           C  
ATOM     30  CG  PRO K 507     148.368  48.054  30.500  1.00 52.96           C  
ATOM     31  CD  PRO K 507     147.830  46.866  31.146  1.00 52.86           C  
ATOM     32  N   THR K 508     148.280  46.081  26.718  1.00 56.87           N  
ATOM     33  CA  THR K 508     149.314  45.527  25.862  1.00 58.60           C  
ATOM     34  C   THR K 508     150.055  46.687  25.200  1.00 59.47           C  
ATOM     35  O   THR K 508     149.406  47.506  24.584  1.00 59.38           O  
ATOM     36  CB  THR K 508     148.673  44.662  24.802  1.00 59.11           C  
ATOM     37  OG1 THR K 508     147.722  45.454  24.094  1.00 60.18           O  
ATOM     38  CG2 THR K 508     147.849  43.457  25.426  1.00 59.39           C  
ATOM     39  N   PRO K 509     151.386  46.794  25.358  1.00 60.96           N  
ATOM     40  CA  PRO K 509     152.142  47.983  24.876  1.00 61.50           C  
ATOM     41  C   PRO K 509     152.342  48.141  23.347  1.00 61.89           C  
ATOM     42  O   PRO K 509     151.974  47.260  22.525  1.00 61.69           O  
ATOM     43  CB  PRO K 509     153.515  47.868  25.594  1.00 61.05           C  
ATOM     44  CG  PRO K 509     153.312  46.836  26.654  1.00 61.61           C  
ATOM     45  CD  PRO K 509     152.284  45.858  26.060  1.00 61.19           C  
ATOM     46  N   VAL K 510     152.951  49.283  23.000  1.00 62.44           N  
ATOM     47  CA  VAL K 510     152.958  49.825  21.628  1.00 63.01           C  
ATOM     48  C   VAL K 510     154.307  50.544  21.283  1.00 62.76           C  
ATOM     49  O   VAL K 510     154.661  51.563  21.889  1.00 62.26           O  
ATOM     50  CB  VAL K 510     151.689  50.811  21.401  1.00 63.36           C  
ATOM     51  CG1 VAL K 510     151.518  51.250  19.917  1.00 63.50           C  
ATOM     52  CG2 VAL K 510     150.363  50.186  21.895  1.00 63.36           C  
TER      53      VAL K 510                                                      
ENDMDL                                                                          
MASTER        0    0    0   39  118    0    0    611308   19    0  126          
END                                                                             
