BMRB's mission is to collect, archive, and disseminate (worldwide in the public domain) the important quantitative data derived from NMR spectroscopic investigations of biological macromolecules. A brief description of the submission process is presented below. For more detailed descriptions of the purpose and processes of BMRB, see BMRB Mission Statement and BMRB Aims and Policies.

Current Database Release

The BMRB database contains NMR data derived from biological molecules. These molecules include, but are not limited to, peptides, proteins, and nucleic acids. NMR data about hemes, cofactors, ligands, polysaccharides, or any other biologically relevant molecules are accepted. The data should be assigned on an atom-specific basis and can be deposited using ADIT-NMR,

Types of NMR Data Currently Handled at BMRB:

(click on the links for complete listings)

• NMR spectral parameters (chemical shifts, coupling constants, time-domain data, spectral peak lists, and RDCs),
• Relaxation data (R1/T1, R2/T2, R1rho/T1rho, heteronulear NOEs),
• Other kinetic data (H-exchange, chemical rates)
• Thermodynamic data (pKa, binding constants,order parameters).

Validation Process

Submissions are checked for completeness (mandatory data), correct syntax, and internal consistency. Potential typographical errors and outliers in the data are brought to the attention of the corresponding author. The author has the option of making corrections or declining suggestions. Before a file is released, BMRB staff members add and verify links to other databases.

Data Export

All data currently are exported only in NMR-STAR format and in an ASCII version of relational database tables. All exported data have the author(s)' name(s) attached to the entry and list the primary publication associated with the BMRB file. Users are requested to acknowledge BMRB in publications: a sample acknowledgment is available from the BMRB web site.

Correction or Revision of Entries

Authors are encouraged to update their BMRB files to take new results into account. Entries may be deleted (from the actively-accessed database) at the author's request. The BMRB staff may modify a file to correct any obvious error or upgrade it to maintain consistency with the data format. Any BMRB-initiated changes that involve data values will be brought to the attention of the author. As entries are updated, a statement describing the revision, the date, and the author of the revision will be added to the revision history loop located near the beginning of the file.