BMRB Entry 15912
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PDB ID: 2k79
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR15912
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Title: Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase PubMed: 19361414
Deposition date: 2008-08-07 Original release date: 2009-05-18
Authors: Andreotti, Amy; Severin, Andrew; Fulton, Donald
Citation: Severin, Andrew; Joseph, Raji; Boyken, Scott; Fulton, Donald; Andreotti, Amy. "Proline isomerization preorganizes the Itk SH2 domian for binding to the Itk SH3 domain" J. Mol. Biol. 387, 726-743 (2009).
Assembly members:
Itk_SH3_domain, polymer, 64 residues, 7356.008 Da.
Itk_SH2_domain, polymer, 117 residues, 12534.314 Da.
Natural source: Common Name: Mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
Itk_SH3_domain: GSPEETLVIALYDYQTNDPQ
ELALRCDEEYYLLDSSEIHW
WRVQDKNGHEGYAPSSYLVE
KSPN
Itk_SH2_domain: GSNNLETYEWYNKSISRDKA
EKLLLDTGKEGAFMVRDSRT
PGTYTVSVFTKAIISENPCI
KHYHIKETNDSPKRYYVAEK
YVFDSIPLLIQYHQYNGGGL
VTRLRYPVCGSPGIHRD
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 1384 |
| 15N chemical shifts | 374 |
| 1H chemical shifts | 2178 |
Additional metadata:
Related Database Links:
| PDB | 2rna 1AWJ 2K79 2K7A 2RN8 2RNA 1luk 1lun 1LUI 1LUK 1LUM 1LUN 2ETZ 2EU0 3S9K |
| BMRB | 11018 16809 16809 5461 |
| DBJ | BAA03129 BAE32118 BAA03129 BAC29830 BAE32118 |
| GB | AAA39337 AAA40518 AAI28375 AAI28376 EDL33821 AAA39337 AAA40518 AAI28375 AAI28376 EDL33821 |
| REF | NP_001102295 NP_001268894 NP_001268895 NP_001268896 NP_001268897 NP_001102295 NP_001268894 NP_001268895 NP_001268897 NP_034713 |
| SP | Q03526 Q03526 |
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