BMRB Entry 17622
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PDB ID: 2yh0
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17622
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Title: Solution structure of the closed conformation of human U2AF65 tandem RRM1 and RRM2 domains
Deposition date: 2011-05-04 Original release date: 2011-08-03
Authors: Mackereth, C.; Madl, T.; Simon, B.; Zanier, K.; Gasch, A.; Sattler, Michael
Citation: Mackereth, C.; Madl, T.; Bonnal, S.; Simon, B.; Zanier, K.; Gasch, A.; Rybin, V.; Valcarcel, J.; Sattler, Michael. "Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF" Nature ., .-..
Assembly members:
HUMAN_U2AF65, polymer, 198 residues, 21491.534 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli
Entity Sequences (FASTA):
HUMAN_U2AF65: GAMARRLYVGNIPFGITEEA
MMDFFNAQMRLGGLTQAPGN
PVLAVQINQDKNFAFLEFRS
VDETTQAMAFDGIIFQGQSL
KIRRPHDYQPLPGMSENPSV
YVPGVVSTVVPDSAHKLFIG
GLPNYLNDDQVKELLTSFGP
LKAFNLVKDSATGLSKGYAF
CEYVDINVTDQAIAGLNGMQ
LGDKKLLVQRASVGAKNA
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 497 |
| 15N chemical shifts | 187 |
| 1H chemical shifts | 939 |
Additional metadata:
Related Database Links:
| UNP | U2AF2_HUMAN |
| BMRB | 17623 |
| PDB | 2YH0 2YH1 |
| DBJ | BAC37309 BAG70075 BAG70201 BAI45669 |
| EMBL | CAA45409 CAA45874 CAA45875 CAF97922 |
| GB | AAH07487 AAH08740 AAH30574 AAH43071 AAH44032 |
| PRF | 1805352A |
| REF | NP_001001217 NP_001012496 NP_001025127 NP_001068804 NP_001080595 |
| SP | P26368 P26369 |
| TPG | DAA19368 |
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