BMRB Entry 30774
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR30774
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Title: NMR structure of the cNTnC-cTnI chimera bound to calcium desensitizer W7 PubMed: 32633482
Deposition date: 2020-07-19 Original release date: 2020-08-31
Authors: Cai, F.; Robertson, I.; Kampourakis, T.; Klein, B.; Sykes, B.
Citation: Cai, F.; Robertson, I.; Kampourakis, T.; Klein, B.; Sykes, B.. "The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers." Acs Chem. Biol. 15, 2289-2298 (2020).
Assembly members:
entity_1, polymer, 125 residues, 14186.127 Da.
entity_CA, non-polymer, 40.078 Da.
entity_V8Y, non-polymer, 369.863 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli BL21(DE3)
Entity Sequences (FASTA):
entity_1: MDDIYKAAVEQLTEEQKNEF
KAAFDIFVLGAEDGSISTKE
LGKVMRMLGQNPTPEELQEM
IDEVDEDGSGTVDFDEFLVM
MVRSMKDDSKGKFKRPTLRR
VRISADAMMQALLGARAKGH
HHHHH
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 505 |
| 15N chemical shifts | 114 |
| 1H chemical shifts | 799 |
Additional metadata:
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